anti-HMGCR Monoclonal Antibody

• Catalog number
  PM-7211
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  HMGCR Monoclonal Antibody: HMG-CoA reductase (HMGCR) is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by HMGCR. Normally in mammalian cells HMGCR is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of HMGCR induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis.
• Gene names
  HMGCR Monoclonal Antibody: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase, HMG coenzyme A reductase, HMG CoAR, LDLCQ3
• Antibodie s label
  unlabelled serum
• Purity
  HMGCR Monoclonal Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Mouse
• Type
  Monoclonal
• Immunoglobulin
  IgG2a
• Spicific to
  At least two isoforms of HMGCR are known to exist.
• Antigen
  Mouse monoclonal HMGCR antibody was made against a 17 amino acid peptide near the amino terminus of human HMGCR.
• Immuno application
  ELISA, Western Blot
• Antibody advice
  HMGCR antibody can be used for detection of HMGCR by Western blot at 2 - 4 ug/mL.
• Suspention pH azide
  HMGCR Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  HMGCR Monoclonal antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year.
• Works with
  Tag
• Omim nr
  4557643
• Ncbi nr
  NP_000850
• KDa
  Predicted: 98 kDa
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  3156
• GENE symbol
  HMGCR
• Antigene name
  3-hydroxy-3-methylglutaryl-CoA reductas
• Source
  homo sapiens
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  HMGCR   Monoclonal  
• Gene symbol
  HMGCR
• Short name
  anti-HMGCR Monoclonal Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Alternative name
  Antibody toHMGCR monoclonal (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:5006
• Gene
  HMGCR
• Long gene name
  3-hydroxy-3-methylglutaryl-CoA reductase
• Synonyms gene name
  • 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
• Synonyms name
  • hydroxymethylglutaryl-CoA reductase
  • 3-hydroxy-3-methylglutaryl CoA reductase (NADPH)
• Locus
  5q13.3
• Discovery year
  2001-06-22
• Entrez gene record
  3156
• VEGA ID
  OTTHUMG00000102069

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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