Anti GPR43 Polyclonal

Anti GPR43 Polyclonal is available 2 times from Bioss polyclonal antibodies labs

GENTObs-13536R-A594 | Anti-GPR43 (Polyclonal), ALEXA Fluor 594size: 100 microliters | 570.66 USD

  • Conjugated with
    ALEXA FLUOR® 594
  • Specificity
    This antibody reacts specifically with GPR43
  • Applications
    FCM, IF(IHC-P)
  • Applications with corresponding dilutions
    FCM(1:20-100), IF(IHC-P)(1:50-200)
  • Excitation emission
    590nm/617nm
  • Also known as
    GPR43 Polyclonal Antibody
  • Other name
    Anti-GPR43 Polyclonal
  • Properties
    For facs or microscopy Alexa 1 conjugate.
  • Conjugation
    Alexa Fluor,ALEXA FLUOR® 594
  • Conjugated
    Alexa conjugate 1
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
  • Group
    Polyclonals and antibodies
  • About
    Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
  • Gene target
  • Short name
    Anti-GPR43 (Polyclonal)
  • Label
    ALEXA FLUOR 594
  • Alternative name
    antibody to-GPR43 (polyclonal), ALEXA Fluor 594
1. Gene info
MeSH Data
  • Name
  • Concept
    Scope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
Additional information

GENTObs-13536R-PE | Anti-GPR43 (Polyclonal), PEsize: 100 microliters | 633.68 USD

Ajax processing
  • Type
    Conjugated Primary Antibody
  • Host organism
    Rabbit (Oryctolagus cuniculus)
  • Target Protein/Peptide
    GPR43
  • Modification
    No modification has been applied to this antibody
  • Modification site
    None
  • Clonality
    Polyclonal Antibody
  • Clone
    Polyclonal Antibodies
  • Concentration
    1ug per 1ul
  • Subcellular locations
    Extracellular
  • Antigen Source
    KLH conjugated synthetic peptide derived from human GPR43
  • Gene ID
    2867
  • Swiss Prot
    O15552
  • Cross reactive species
    Human (Homo sapiens), Mouse (Mus musculus)
  • Cross Reactive Species details
    No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
  • Background information
    G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes (PubMed:21037097).
  • Purification method
    Purified by Protein A.
  • Storage
    Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
  • Synonyms
    FFA2R; GPR43; Free fatty acid receptor 2; G-protein coupled receptor 43; FFAR2; FFA2; GPCR43
  • Advisory
    Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
  • Technique
    Polyclonal, anti
  • Alternative technique
    polyclonals
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