FOXA2/HNF 3beta Antibody, ALEXA FLUOR 594

• Catalog number
  bs-2358R-A594
• Price
  Please ask
• Size
  100ul

• Long name
  FOXA2/HNF 3beta Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
• Also known as
  Anti-FOXA2/HNF 3beta PAb ALEXA FLUOR 594
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 594
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  FOXA2/HNF 3beta
• Specificity
  This is a highly specific antibody against FOXA2/HNF 3beta.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  200-250/457
• Subcellular location
  Cytoplasm, Nucleus
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HNF 3 beta
• Gene ID Number
  3170
• Swiss Prot
  Q9Y261
• Tested applications
  FCM, IF(IHC-P)
• Recommended dilutions
  FCM(1:20-100), IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  590nm/617nm
• Synonyms
  HNF3B; TCF3B; Hepatocyte nuclear factor 3-beta; HNF-3-beta; HNF-3B; Forkhead box protein A2; Transcription factor 3B; TCF-3B; FOXA2
• Properties
  For facs or microscopy Alexa 1 conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• French translation
  anticorps

• Gene target
  FOXA2/HNF   3beta  
• Gene symbol
  FOXA2, ONECUT1, FOXM1
• Short name
  Anti-FOXA2/HNF 3beta
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  FOXA2/HNF 3beta Polyclonal Antibody, ALEXA FLUOR 594
• Alternative technique
  antibodies
• Alternative to gene target
  forkhead box A2, HNF3B and TCF3B, FOXA2 and IDBG-59234 and ENSG00000125798 and 3170, transcription regulatory region DNA binding, nuclei, Foxa2 and IDBG-208945 and ENSMUSG00000037025 and 15376, FOXA2 and IDBG-648756 and ENSBTAG00000012407 and 503580

Gene info

• Identity
  HGNC:5022
• Gene
  FOXA2
• Long gene name
  forkhead box A2
• Synonyms gene
  • HNF3B
• Synonyms gene name
  • hepatocyte nuclear factor 3, beta
• GenBank acession
  • AF147787
• Locus
  20p11.21
• Discovery year
  1998-02-11
• Entrez gene record
  3170
• Pubmed identfication
  • 9119385
  • 11875061
• Classification
  • Forkhead boxes
• VEGA ID
  OTTHUMG00000191876

Gene info

• Identity
  HGNC:8138
• Gene
  ONECUT1
• Long gene name
  one cut homeobox 1
• Synonyms gene
  • HNF6
  • HNF6A
• Synonyms gene name
  • one cut domain, family member 1
• Synonyms
  • HNF-6
• GenBank acession
  • U77975
• Locus
  15q21.3
• Discovery year
  2000-02-11
• Entrez gene record
  3175
• Pubmed identfication
  • 8887657
  • 8790352
• Classification
  • CUT class homeoboxes and pseudogenes
• VEGA ID
  OTTHUMG00000131899

Gene info

• Identity
  HGNC:3818
• Gene
  FOXM1
• Long gene name
  forkhead box M1
• Synonyms gene
  • FKHL16
• Synonyms
  • HFH-11
  • trident
  • HNF-3
  • INS-1
  • MPP2
  • MPHOSPH2
  • TGT3
• Synonyms name
  • M-phase phosphoprotein 2
• GenBank acession
  • Y12773
• Locus
  12p13.33
• Discovery year
  1997-07-25
• Entrez gene record
  2305
• Pubmed identfication
  • 9032290
  • 9441747
• RefSeq identity
  • NM_021953
• Classification
  • Forkhead boxes
• VEGA ID
  OTTHUMG00000168118

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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