anti-Caspase-4 Antibody

• Catalog number
  49-582
• Price
  Please ask
• Size
  0.05 mg

• Gene info
  Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1b and IL-18. Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells. More recent studies have shown that it can be activated by ER stress and has been suggested to be involved in multiple neuronal pathologies such as Alzheimer’s disease. The rodent homolog is known as Caspase 4 and Caspase 11.
• Gene names
  CASP4, CASP-4, Casp11, Caspase 4, Caspase-4, Cysteine protease icerel-ii, ICE(rel)-II, ICE(rel)II, ICH-2, Ich-3, ICH2, Protease ICH-2, TX, Tx protease, Caspase 11, ICEREL-II, Mih1/TX, Protease TX
• Antibodie s label
  unlabelled serum
• Purity
  Immunoaffinity Chromatography
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Antigen
  Synthetic peptide from human CASP4 / Caspase 4.
• Immuno application
  Western Blot, immuno-histo-chemistry
• Antibody advice
  Caspase-4 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, immunohistochemistry starting at 5 ug/mL, and immunofluorescence starting at 10 ug/mL.
• Suspention pH azide
  PBS, 0.02% sodium azide.
• Keep at
  Aliquot and store Caspase-4 antibody at -20 grades C. As with all antibodies avoid freeze/thaw cycles.
• Works with
  Human, Mouse
• Omim nr
  1352420
• Ncbi nr
  P49662
• Vial with antibody
  in solution
• NCBI GENE nr
  837
• GENE symbol
  CASP4
• Antigene name
  caspase 4, apoptosis-related cysteine peptidase
• Source
  Homo sapiens
• Protein nr
  P49662
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use. Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Caspase-4  
• Gene symbol
  CASP4, CASP4LP, CASP8AP2
• Short name
  anti-Caspase-4 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toCasp-4 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:1505
• Gene
  CASP4
• Long gene name
  caspase 4
• Synonyms gene name
  • caspase 4, apoptosis-related cysteine protease
  • caspase 4, apoptosis-related cysteine peptidase
• Synonyms
  • ICE(rel)II
  • ICH-2
  • TX
• GenBank acession
  • U25804
• Locus
  11q22.3
• Discovery year
  1996-07-22
• Entrez gene record
  837
• Pubmed identfication
  • 7797510
  • 9250871
• RefSeq identity
  • NM_001225
• Classification
  • Caspases
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000166078

Gene info

• Identity
  HGNC:53657
• Gene
  CASP4LP
• Long gene name
  caspase 4 like, pseudogene
• Synonyms gene
  • CASP17P
• Synonyms gene name
  • caspase 17, pseudogene
• Locus
  11q22.3
• Discovery year
  2018-06-20
• Entrez gene record
  643733
• RefSeq identity
  • NR_034078

Gene info

• Identity
  HGNC:1510
• Gene
  CASP8AP2
• Long gene name
  caspase 8 associated protein 2
• Synonyms gene name
  • CASP8 associated protein 2
• Synonyms
  • FLASH
  • CED-4
  • RIP25
  • FLJ11208
  • KIAA1315
• Synonyms name
  • FLICE-associated huge protein
• GenBank acession
  • AB037736
• Locus
  6q15
• Discovery year
  1999-12-10
• Entrez gene record
  9994
• Pubmed identfication
  • 10235259
  • 17245429
  • 17003126
• RefSeq identity
  • NM_001137667
• VEGA ID
  OTTHUMG00000015212

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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