anti-EGFR Antibody

anti-EGFR Antibody is available 1 time from Biovision labs

3782-100 | anti-EGFR Antibodysize: EGFR Antibody | 397.45 USD

Ajax processing
  • Target of this antibody:
    EGFR
  • Alternative names of antibody target:
    EGFR, Epidermal Growth Factor Receptor, ERBB, ERBB1, ERBB-1, Erythroblastic Leukemia viral (v-erb-b) oncogene homolog
  • Background information:
    The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Exons in the EGFR gene product are frequently either deleted or duplicated to produce deletion mutants (DM) or tandem duplication mutants (TDM), respectively, which are detected at various molecular weights. EGFR binds several ligands, including epidermal growth factor (EGF), transforming growth factor α (TGFα), Amphiregulin and heparin binding-EGF (HB-EGF). Ligand binding promotes the internalization of EGFR via Clathrin-coated pits and its subsequent degradation in response to its intrinsic tyrosine kinase. EGFR is involved in organ morphogenesis and maintenance and repair of tissues, but upregulation of EGFR is associated with tumor progression. The oncogenic effects of EGFR include initiation of DNA synthesis, enhanced cell growth, invasion and metastasis. Abrogation of EGFR results in cell cycle arrest, apoptosis or dedifferentiation of cancer cells, suggesting that EGFR may be an effective therapeutic target.
  • Antibody host:
    Rabbit
  • Clonality of antibody:
    Polyclonal
  • Isotype:
    Rabbit IgG
  • This antibody reacts with:
    Human, mouse
  • Immunogene sequence:
    Synthetic peptide of human EGFR
  • Concentration of antibody:
    N/A
  • Form of antibody:
    Liquid
  • Formulation of this antibody:
    100 µl affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.
  • Purification method:
    Affinity purified
  • This antibody has been succesfully tested for use in following methods:
    Western blot, Immunoprecipitation
  • Recommended usage:
    Western blotting (1:500 – 1:2500) and Immunoprecipitation. However, the optimal concentrations should be determined individually. The antibody recognizes the EGFR of human and mouse origins. Reactivity to other species has not been tested.
  • Storage information:
    Shelf time: 12 months in temp.: -20 deg.C
  • Shipping conditions:
    gel pack
  • How to handle this antibody:
    The antibody solution should be gently mixed before use.
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
  • Properties
    If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
    anticorps
  • Gene target
  • Short name
    anti-EGFR Antibody
  • Technique
    Antibody, anti
  • Alternative name
    antibody to-epidermal growth factor receptor (Antibody to)
  • Alternative technique
    antibodies
  • Alternative to gene target
    epidermal growth factor receptor, ERBB and ERBB1 and HER1 and mENA and PIG61, EGFR and IDBG-16933 and ENSG00000146648 and 1956, transferase activity, nuclei, Egfr and IDBG-151194 and ENSMUSG00000020122 and 13649, EGFR and IDBG-644035 and ENSBTAG00000011628 and 407217
Simillar products
Supplier:MBS Monoclonals
Price:480.94USD
Supplier:NJS poly
Price:477.42USD
Supplier:MyBioSource
Price:259.87USD
Supplier:aviva
Price:498.58USD
Supplier:MyBioSource
Price:0.00USD
Supplier:Bluegen antibodies
Price:546.79USD
Supplier:MyBioSource
Price:0.00USD
Supplier:MBS Polyclonals
Price:311.61USD
Supplier:proscience
Price:211.66USD
Supplier:MyBioSource
Price:630.28USD
Supplier:trca
Price:186.97USD
Supplier:MBS Monoclonals
Price:475.06USD
Supplier:Bioss Primary Unconjugated Antibodies
Price:385.70USD
Supplier:Brady Benelux NL
Price:310.44USD
Supplier:trca
Price:127.00USD
Supplier:MyBioSource
Price:1 682.71USD
Filters
+32-(0)1-658-90-45 lieven@gentaur.com
anti-EGFR Antibody - Gentaur.com
Contact
Chat with gentaur.com employee