EDEM2 Antibody

• Catalog number
  6633-30T
• Price
  Please ask
• Size
  30 μg

• Antibody Target
  EDEM2
• Target Alternative Name
  ER degradation-enhancing alpha-mannosidase-like protein 2
• Antibody Type
  Polyclonal
• Species Reactivities
  Human, mouse, rat
• Immunogen Sequence
  Synthetic peptide C-terminal
• Accession
  Q9BV94
• Gene Id
  55741
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  0.5 mg/ml
• Formulation
  30 µg (0.5 mg/ml) polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
• Purification
  Affinity purified antibody
• Application
  Western blot
• Positive Control
  Western Blot: Rat kidney lysate
• Application And Usages
  Western blot: 1:200
• Description
  Proteins expressed in the endoplasmic reticulum (ER) are tightly regulated by a variety of quality control mechanisms. Terminally misfolded proteins in the ER are retrotranslocated to the cytoplasm and degraded by proteasomes through a mechanism known as ER-associated degradation (ERAD). EDEM2 (ER degradation-enhancing alpha-mannosidase-like 2) is a 578 amino acid secreted protein that, in conjunction with other EDEM proteins (namely EDEM and EDEM3), is involved in the ERAD pathway of protein degradation. EDEM2, a member of the glycosyl hydrolase 47 family, contains a mannosidase homology domain, an N-terminal cleavable signal sequence and a C-terminal extension that is required for both ER retention and the proper function of EDEM2. Human EDEM2 shares 93% sequence identity with its mouse homolog, suggesting a conserved role between species. Two isoforms of EDEM2 exist due to alternative splicing events.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  EDEM2  
• Gene symbol
  EDEM2
• Short name
  EDEM2 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  EDEM2 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:15877
• Gene
  EDEM2
• Long gene name
  ER degradation enhancing alpha-mannosidase like protein 2
• Synonyms gene
  • C20orf49
  • C20orf31
• Synonyms gene name
  • chromosome 20 open reading frame 31
  • ER degradation enhancer, mannosidase alpha-like 2
• Synonyms
  • FLJ10783
  • bA4204.1
• GenBank acession
  • AK001645
• Locus
  20q11.22
• Discovery year
  2001-06-21
• Entrez gene record
  55741
• Pubmed identfication
  • 15537790
  • 15579471
• RefSeq identity
  • NM_018217
• Classification
  • Mannosidases alpha class 1
• VEGA ID
  OTTHUMG00000032322

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

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