recMAb™ Anti-ATRX/RAD54 Antibody

• Catalog number
  A2216-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  ATRX
• Target Alternative Name
  JMS, XH2, XNP, MRX52, RAD54, RAD54L, ZNF-HX, MRXHF1, SFM1, SHS, ATR2
• Antibody Type
  Monoclonal
• Clone
  ATRX/2900R
• Species Reactivities
  Human
• Immunogen Sequence
  Recombinant human ATRX protein
• Accession
  P46100
• Gene Id
  546
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  1 mg/ml
• Formulation
  In 10 mM PBS
• Purification
  Protein A/G purified
• Application
  Immunohistochemistry (IHC)
• Application And Usages
  IHC (1-2 µg/ml)
• Description
  The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
• Storage Condition
  -20ºC
• Shipping Condition
  Gel Pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Data Sheet Link
• Additional description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  recMAb™   ATRX/RAD54  
• Gene symbol
  ATRX
• Short name
  recMAb™ Anti-ATRX/RAD54 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Isotype
  IgG
• Alternative name
  recMAb™ Antibody toATRX/RAD54 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:886
• Gene
  ATRX
• Long gene name
  ATRX chromatin remodeler
• Synonyms gene
  • RAD54
  • JMS
  • MRX52
• Synonyms gene name
  • alpha thalassemia/mental retardation syndrome X-linked (RAD54 (S. cerevisiae) homolog)
  • Juberg-Marsidi syndrome
  • mental retardation, X-linked 52
  • alpha thalassemia/mental retardation syndrome X-linked
• Synonyms
  • XH2
  • XNP
• Synonyms name
  • RAD54 homolog (S. cerevisiae)
• GenBank acession
  • U72937
• Locus
  Xq21.1
• Discovery year
  1992-11-27
• Entrez gene record
  546
• Pubmed identfication
  • 7874112
  • 1415255
  • 8503439
  • 8630485
• RefSeq identity
  • NM_000489
• Classification
  • RNA helicases
• VEGA ID
  OTTHUMG00000022686
• Locus Specific Databases
  • Global Variome shared LOVD
  • The Globin Gene Server
  • LRG_1153

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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