anti-Smac Antibody

• Catalog number
  2409
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  Smac Antibody: The inhibitor of apoptosis proteins (IAPs) regulate programmed cell death by inhibiting members of the caspase family of enzymes. A novel mammalian protein that binds to IAPs and neutralizes the inhibitory effect of IAPs on caspases was recently identified and designated Smac/DIABLO. Smac/DIABLO is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates cytochrome c/Apaf-1/capase-9 pathway. Analysis of the structural basis of Smac/DIABLO reveals that the N-terminal amino acids are required for binding of Smac/DIABLO to IAPs and activation of caspases. Smac/DIABLO is expressed in a variety of human and mouse tissues.
• Gene names
  Smac Antibody: Smac, AU040403, 0610041G12Rik, 1700006L01Rik, Smac, Diablo homolog, mitochondrial, Direct IAP-binding protein with low pI
• Antibodie s label
  unlabelled serum
• Purity
  Smac Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Antigen
  Smac antibody was made against a 15 amino acid peptide near the carboxy terminus of human Smac.
• Immuno application
  ELISA, Western Blot, immuno-histo-chemistry, immuno precipitation
• Antibody advice
  Smac antibody can be used for detection of Smac/DIABLO by Western blot at 1 ug/mL. A 25 kDa band can be detected. Smac antibody can also be used to detect Smac/DIABLO by immunohistochemistry at 5 ug/mL.
• Suspention pH azide
  Smac Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  Smac antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human, Mouse, Rat
• Omim nr
  8953908
• Ncbi nr
  AF203914
• KDa
  25 kDa
• Vial with antibody
  in solution
• NCBI GENE nr
  66593
• GENE symbol
  Diablo
• Antigene name
  diablo homolog (Drosophila)
• Source
  Mus musculus
• Protein nr
  Q9JIQ3
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Smac  
• Gene symbol
  DIABLO
• Short name
  anti-Smac Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toSmac (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:21528
• Gene
  DIABLO
• Long gene name
  diablo IAP-binding mitochondrial protein
• Synonyms gene name
  • diablo, IAP-binding mitochondrial protein
• Synonyms
  • SMAC
  • DIABLO-S
  • FLJ25049
  • FLJ10537
  • DFNA64
• Synonyms name
  • second mitochondria-derived activator of caspase
• GenBank acession
  • AF262240
• Locus
  12q24.31
• Discovery year
  2003-10-27
• Entrez gene record
  56616
• Pubmed identfication
  • 12749848
  • 17237824
  • 21722859
• RefSeq identity
  • NM_019887
• VEGA ID
  OTTHUMG00000157014

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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