DCTN1 Antibody, ALEXA FLUOR 594

• Catalog number
  bs-6929R-A594
• Price
  Please ask
• Size
  100ul

• Long name
  DCTN1 Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
• Also known as
  Anti-DCTN1 PAb ALEXA FLUOR 594
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 594
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  DCTN1
• Specificity
  This is a highly specific antibody against DCTN1.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DCTN1/Dynactin 1
• Gene ID Number
  1639
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.Tissue specificity; Brain.Involvement in disease; Defects in DCTN1 are the cause of distal hereditary motor neuronopathy type 7B (HMN7B); also known as progressive lower motor neuron disease (PLMND). HMN7B is a neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.Defects in DCTN1 are a cause of susceptibility to amyotrophic lateral sclerosis (ALS). ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.Defects in DCTN1 are the cause of Perry syndrome (PERRYS); also called parkinsonism with alveolar hypoventilation and mental depression. Perry syndrome is a neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss. Parkinsonism develops later and respiratory failure occurred terminally.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  590nm/617nm
• Synonyms
  Alternative names150 kDa dynein associated polypeptide; 150 kDa dynein-associated polypeptide; DAP 150; DAP-150; DAP150; DCTN 1; DCTN1; DCTN1_HUMAN; DP 150; DP-150; DP150; Dynactin 1 p150 Glued Drosophila homolog; Dynactin 1 p150 glued homolog Drosophila; Dynactin 1; Dynactin subunit 1; Dynactin1; HMN7B; P135; p150 Glued Drosophila homolog; p150 glued; p150 glued homolog; p150GLUED DROSOPHILA HOMOLOG OF; p150-glued; p150glued.
• Properties
  For facs or microscopy Alexa 1 conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• French translation
  anticorps

• Gene target
  DCTN1  
• Gene symbol
  DCTN1, DCTN1-AS1
• Short name
  Anti-DCTN1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  DCTN1 Polyclonal Antibody, ALEXA FLUOR 594
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:2711
• Gene
  DCTN1
• Long gene name
  dynactin subunit 1
• Synonyms gene name
  • dynactin 1 (p150, Glued (Drosophila) homolog)
• Synonyms name
  • p150 glued homolog (Drosophila)
• Locus
  2p13.1
• Discovery year
  1995-10-03
• Entrez gene record
  1639
• Pubmed identfication
  • 1828535
• RefSeq identity
  • NM_004082
• Classification
  • Dynactin subunits
• VEGA ID
  OTTHUMG00000129963
• Locus Specific Databases
  • Inherited Peripheral Neuropathies Mutation Database
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database
  • LRG_237

Gene info

• Identity
  HGNC:44151
• Gene
  DCTN1-AS1
• Long gene name
  DCTN1 antisense RNA 1
• Synonyms gene name
  • DCTN1 antisense RNA 1 (non-protein coding)
• GenBank acession
  • BC042946
• Locus
  2p13.1
• Discovery year
  2012-06-30
• Entrez gene record
  100189589
• RefSeq identity
  • NR_024463
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000152826

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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