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Gene info
CYP1A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. CYP1A1 has been associated with lung cancer risk. This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
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Gene names
CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX
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Antibodie s label
unlabelled serum
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Purity
Antibody is purified by peptide affinity chromatography method.
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Ab raised in
Rabbit
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Type
Polyclonal
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Antigen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CYP1A1.
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Immuno application
ELISA, Western Blot
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Antibody advice
CYP1A1 antibody can be used for detection of CYP1A1 by ELISA at 1:1562500. CYP1A1 antibody can be used for detection of CYP1A1 by western blot at 1 ug/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
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Suspention pH azide
Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL.
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Keep at
For short periods of storage (days) store at 4 grades C. For longer periods of storage, store CYP1A1 antibody at -20 grades C. As with any antibody avoid repeat freeze-thaw cycles.
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Works with
Human, Mouse
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Omim nr
4503199
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Ncbi nr
NP_000490
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KDa
58 kDa
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Vial with antibody
Lyophilized
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Quantity per ml
1 mg/ml
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NCBI GENE nr
1543
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GENE symbol
CYP1A1
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Antigene name
cytochrome P450, family 1, subfamily A, polypeptide 1
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Source
Homo sapiens
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Protein nr
P04798
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
CYP1A1
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Short name
anti-CYP1A1 Antibody
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative name
Antibody tocytochrome P450, family 1, subfamily A, polypeptide 1 (antibody to-)
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Alternative technique
antibodies
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Alternative to gene target
cytochrome P450, family 1, subfamily A, polypeptide 1, AHH and AHRR and CP11 and CYP1 and P1-450 and P450-C and P450DX, CYP1A1 and IDBG-22475 and ENSG00000140465 and 1543, oxidoreductase activity, Cytoplasm, Cyp1a1 and IDBG-170677 and ENSMUSG00000032315 and 13076, CYP1A1 and IDBG-631735 and ENSBTAG00000001021 and 282870
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