Anti-Centaurin gamma 1 (Polyclonal), ALEXA Fluor 594

• Catalog number
  GENTObs-5930R-A594
• Price
  Please ask
• Size
  100 microliters

• Type
  Conjugated Primary Antibody
• Conjugated with
  ALEXA FLUOR® 594
• Host organism
  Rabbit (Oryctolagus cuniculus)
• Target Protein Peptide
  Centaurin gamma 1
• Specificity
  This antibody reacts specifically with Centaurin gamma 1
• Modification
  No modification has been applied to this antibody
• Modification site
  None
• Clonality
  Polyclonal Antibody
• Clone
  Polyclonal Antibodies
• Concentration
  1ug per 1ul
• Subcellular locations
  N/A
• Antigen Source
  KLH conjugated synthetic peptide derived from human Centaurin gamma 1
• Gene ID
  N/A
• Swiss Prot
  N/A
• Applications
  IF(IHC-P)
• Applications with corresponding dilutions
  IF(IHC-P)(1:50-200)
• Cross reactive species
  Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
• Cross Reactive Species details
  No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
• Background information
  GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
• Purification method
  Purified by Protein A.
• Storage
  Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
• Excitation emission
  590nm/617nm
• Synonyms
  Centaurin gamma 1; ANK repeat and PH domain-containing protein 2; AGAP-2; Agap2; Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2; AGAP2_HUMAN; ANK repeat and PH domains 2; Arf GAP with GTP binding protein like; Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2; Arf GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2; Arf-GAP with GTPase; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; ArfGAP with GTPase domain, ankyrin repeat and PH domain 2; centaurin gamma1; Centaurin-gamma-1; Centg1; cnt g1; Cnt-g1; Cnt2; GGAP2; GTP binding and GTPase activating protein 2; GTP-binding and GTPase activating protein 2; GTP-binding and GTPase-activating protein 2; Nuclear GTPase PIKE; Phosphatidylinositol-3-kinase enhancer; Phosphoinositide 3 kinase enhancer; PI3K ENHANCER; PIKE.
• Also known as
  Centaurin gamma 1 Polyclonal Antibody
• Other name
  Anti-Centaurin gamma 1 Polyclonal
• Advisory
  Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
• Properties
  For facs or microscopy Alexa 1 conjugate.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

• Gene target
  Centaurin   gamma  
• Gene symbol
  AGAP1, AGAP2, AGAP4
• Short name
  Anti-Centaurin gamma 1
• Technique
  Polyclonal, anti-, anti, antibody to, antibodies, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  Centaurin gamma 1 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
• Alternative technique
  polyclonals, antibodies

Gene info

• Identity
  HGNC:16922
• Gene
  AGAP1
• Long gene name
  ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
• Synonyms gene
  • CENTG2
• Synonyms gene name
  • centaurin, gamma 2
• Synonyms
  • KIAA1099
  • GGAP1
• GenBank acession
  • AF413078
• Locus
  2q37.2
• Discovery year
  2001-10-29
• Entrez gene record
  116987
• Pubmed identfication
  • 12388557
• RefSeq identity
  • NM_014914
• Classification
  • ArfGAPs
  • BAR-PH domain containing
  • Ankyrin repeat domain containing
• VEGA ID
  OTTHUMG00000133293

Gene info

• Identity
  HGNC:16921
• Gene
  AGAP2
• Long gene name
  ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
• Synonyms gene
  • CENTG1
• Synonyms gene name
  • centaurin, gamma 1
• GenBank acession
  • AF413077
• Locus
  12q14.1
• Discovery year
  2001-10-29
• Entrez gene record
  116986
• Pubmed identfication
  • 16079295
• RefSeq identity
  • NM_014770
• Classification
  • BAR-PH domain containing
  • Ankyrin repeat domain containing
  • ArfGAPs
• VEGA ID
  OTTHUMG00000170285

Gene info

• Identity
  HGNC:23459
• Gene
  AGAP4
• Long gene name
  ArfGAP with GTPase domain, ankyrin repeat and PH domain 4
• Synonyms gene
  • CTGLF1
  • AGAP8
  • CTGLF5
• Synonyms gene name
  • centaurin, gamma-like family, member 1
  • ArfGAP with GTPase domain, ankyrin repeat and PH domain 8
  • centaurin, gamma-like family, member 5
• Synonyms
  • Em:AC012044.1
  • MRIP2
• GenBank acession
  • AF411132
• Locus
  10q11.22
• Discovery year
  2004-05-27
• Entrez gene record
  119016
• Pubmed identfication
  • 12477932
• RefSeq identity
  • NM_133446
• Classification
  • ArfGAPs
  • Ankyrin repeat domain containing
  • BAR-PH domain containing
• VEGA ID
  OTTHUMG00000018088

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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