anti-Integrin alpha 4 Antibody
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Catalog number
4827
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Price
Please ask
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Size
0.02 mg, 0.1 mg
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Gene info
Integrin alpha 4 Antibody: The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta1, the gut mucosal homing receptor for peripheral T cells. At least two isoforms are known to exist.
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Gene names
Integrin alpha 4 Antibody: IA4, CD49D, Integrin alpha-4, CD49 antigen-like family member D
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Antibodie s label
unlabelled serum
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Purity
Integrin alpha 4 Antibody is affinity chromatography purified via peptide column.
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Ab raised in
Rabbit
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Type
Polyclonal
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Immunoglobulin
IgG
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Antigen
Integrin alpha 4 antibody was made against a 16 amino acid synthetic peptide from near the center of human Integrin alpha 4.
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Immuno application
ELISA, Western Blot, immuno fluorescence
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Antibody advice
Integrin alpha 4 antibody can be used for the detection of Integrin alpha 4 by Western blot at 1 ug/mL. Despite its predicted molecular weight, Integrin alpha4 will often run at higher molecular weight in SDS-PAGE. Antibody can also be used for immunoflourescence starting at 2 ug/mL.
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Suspention pH azide
Integrin alpha 4 Antibody is supplied in PBS containing 0.02% sodium azide.
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Keep at
Integrin alpha 4 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Works with
Human, Mouse, Rat
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Omim nr
67191027
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Ncbi nr
NP_000876
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Vial with antibody
in solution
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Quantity per ml
1 mg/mL
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NCBI GENE nr
3676
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GENE symbol
ITGA4
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Antigene name
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
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Source
Homo sapiens
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Protein nr
P13612
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Description
The anti-Integrin alpha 4 Antibody is a α- or alpha protein sometimes glycoprotein present in blood. This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
ITGA9, ITGA4, ITGAX
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Short name
anti-Integrin alpha 4 Antibody
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative name
Antibody toIntegrin a 4 (antibody to-)
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Alternative technique
antibodies
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Gene info
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Identity
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Gene
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Long gene name
integrin subunit alpha 9
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Synonyms gene name
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
1994-05-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
integrin subunit alpha 4
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Synonyms gene
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Synonyms gene name
- integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
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Synonyms
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Synonyms name
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Locus
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Discovery year
1991-08-06
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Entrez gene record
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Pubmed identfication
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Classification
- CD molecules
- Integrin alpha subunits
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
integrin subunit alpha X
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Synonyms gene
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Synonyms gene name
- integrin, alpha X (antigen CD11C (p150), alpha polypeptide)
- integrin, alpha X (complement component 3 receptor 4 subunit)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
1988-08-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Integrin alpha subunits
- Complement system regulators and receptors
- CD molecules
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VEGA ID
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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