anti-CBFb polyclonal antibody

anti-CBFb polyclonal antibody is available 1 time from Biovision labs

  • Target of this antibody:
    CBFb
  • Alternative names of antibody target:
    PEBP2B, CBF-beta, PEA2-beta, PEB2-beta
  • Background information:
    CBFb represents the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family. These transcription factors regulate a host of genes specific to hematopoiesis (e.g. RUNX1) and osteogenesis (e.g. RUNX2). The beta subunit is the regulatory subunit which allosterically enhances the activity of the DNA binding alpha subunit as the complex binds to the core site of various enhancers and promoters. CBFb can be involved in a chromosomal rearrangement of chromosome 16 (inv(16)(p13q22)) which produces a fusion protein consisting of the N terminus of CBFb and the C-terminal portion of MYH11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype.
  • Antibody host:
    Rabbit
  • Clonality of antibody:
    Polyclonal
  • Isotype:
    Rabbit IgG
  • Clone:
    N/A
  • This antibody reacts with:
    Human.
  • Immunogene sequence:
    Polyclonal antibody raised in rabbit against human CBFb (core-binding factor, beta subunit) using two KLH conjugated synthetic peptides containing sequences from the central region of the protein.
  • Concentration of antibody:
    N/A
  • Form of antibody:
    Liquid
  • Formulation of this antibody:
    In PBS with 0.05% (W/V) sodium azide.
  • Purification method:
    Whole Anti-Sera
  • This antibody has been succesfully tested for use in following methods:
    ELISA, ChIP.
  • Recommended usage:
    ChIP: 4 µl/ChIP, ELISA: 1:500.
  • Storage information:
    Shelf time: 12 months in temp.: -20 deg.C
  • Shipping conditions:
    gel pack
  • How to handle this antibody:
    The antibody solution should be gently mixed before use.
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
  • Properties
    If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • Group
    Polyclonals and antibodies
  • About
    Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
  • French translation
    anticorps
  • Gene target
  • Short name
    anti-CBFb polyclonal antibody
  • Technique
    Polyclonal, Antibody, anti
  • Alternative name
    antibody to-CBFb polyclonal (Antibody to)
  • Alternative technique
    polyclonals

6835-50 | anti-CBFb polyclonal antibodysize: CBFb polyclonal antibody | 388.96 USD

  • Catalog number
    6835-50
  • Supplier
  • Price
    388.96 USD
  • Size
    CBFb polyclonal antibody
1. Gene info
MeSH Data
  • Name
  • Concept
    Scope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
Additional information
Product images
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