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Target antigen
Calmodulin
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
mouse
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Analyses
WB,IHC-P
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Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Calmodulin(119-136aa DEEVDEMIREADIDGDGQ), identical to the related rat and mouse sequences.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the Calmodulin Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The Calmodulin Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
Calmodulin, calcium-modulated protein, is a calcium-binding protein expressed in all eukaryotic cells. It can bind to and regulate a number of different protein targets, thereby affecting many different cellular functions. Calmodulin mediates processes such as inflammation, metabolism, apoptosis, smooth muscle contraction, intracellular movement, short-term and long-term memory, nerve growth and the immune response. Calmodulin is expressed in many cell types and can have different subcellular locations, including the cytoplasm, within organelles, or associated with the plasma or organelle membranes. Many of the proteins that Calmodulin binds are unable to bind calcium themselves, and as such use Calmodulin as a calcium sensor and signal transducer. Calmodulin can also make use of the calcium stores in the endoplasmic reticulum, and the sarcoplasmic reticulum. Calmodulin undergoes a conformational change upon binding to calcium, which enables it to bind to specific proteins for a specific response. Calmodulin can bind up to four calcium ions, and can undergo post-translational modifications, such as phosphorylation, acetylation, methylation and proteolytic cleavage, each of which has potential to modulate its actions. Calmodulin can also bind to edema factor toxin from the anthrax bacteria. Calmodulin is the archetype of the family of calcium-modulated proteins of which nearly 20 members have been found. Calmodulin contains 149 amino acids and has 4 calcium-binding domains. Its functions include roles in growth and the cell cycle as well as in signal transduction and the synthesis and release of neurotransmitters. Three calmodulin genes(CALM1, CALM2, and CALM3) map to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3, respectively.
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Related articles
1. Berchtold, M. W.; Egli, R.; Rhyner, J. A.; Hameister, H.; Strehler, E. E. : Localization of the human bona fide calmodulin genes CALM1, CALM2, and CALM3 to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3. Genomics 16: 461-465, 1993. 2. Stevens FC .: Calmodulin: an introduction . Can. J. Biochem. Cell Biol. 61 (8): 906–10, 1983.
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Gene Name
CALM1&CALM2&CALM3
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Protein Name
Calmodulin(CaM)
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Gene Full Name
calmodulin 1(phosphorylase kinase, delta)|calmodulin 2(phosphorylase kinase, delta)|calmodulin 3(phosphorylase kinase, delta)
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Synonyms
CALM 1 antibody|CALM 2 antibody|CALM 3 antibody|CALM antibody|CALM_HUMAN antibody|CALM1 antibody|CALM2 antibody|CALM3 antibody|CALML2 antibody|calmodulin 1(phosphorylase kinase, delta) antibody|Calmodulin 1 antibody|Calmodulin 2(phosphorylase kinase, delta) antibody|Calmodulin 3(phosphorylase kinase, delta) antibody|Calmodulin antibody|Calmodulin1 antibody|CAM 1 antibody|CAM 2 antibody|CAM 3 antibody|CaM antibody|CAM I antibody|CAM1 antibody|CAM2 antibody|CAM3 antibody|CAMB antibody|CAMC antibody|CAMI antibody|CAMII antibody|CAMIII antibody|CPVT4 antibody|DD132 antibody|FLJ99410 antibody|LP7057 protein antibody|PHKD antibody|PHKD antibody|PHKD2 antibody|PHKD3 antibody|Phosphorylase kinase delta antibody|Phosphorylase kinase delta subunit antibody|phosphorylase kinase, delta subunit antibody
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Uniprot ID
P62158
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
