anti-Calcium-Sensing Receptor Antibody

• Catalog number
  49-156
• Price
  Please ask
• Size
  0.05 mg

• Gene info
  CASR, a Calcium-Sensing Receptor, functions as a sensor in parathyroid and kidney to determine extracellular calcium concentration and to maintain calcium homeostasis. This receptor regulates both secretion of parathyroid hormone and excretion of urinary calcium. Mutations that inactivate CASR cause familial hypocalciuric hypercalcemia, which is also correlated with hyperparathyroidism. On the other hand, mutations that activate CASR cause autosomal dominant hypocalcemia. Hjalm et al. (2001) and Awata et al. (2001) have identified the binding of filamin-1 to the C-terminal tail of CASR, which may contribute to its localization in caveolae, link it to the actin-based cytoskeleton, and participate in CASR-mediated activation of MAPK. Multiple isoforms for CASR are produced by alternative splicing.
• Gene names
  CASR, Ca sensing receptor, Ca2+ sensing receptor, Calcium-sensing receptor, FIH, EIG8, GPRC2A, HHC, HHC1, Hypocalciuric hypercalcemia 1, PCAR1, NSHPT, CAR, FHH
• Antibodie s label
  unlabelled serum
• Purity
  Immunoaffinity Chromatography
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Antigen
  Calcium - Sensing Receptor antibody was made against a synthetic peptide derived from the N-Terminus of Calcium - Sensing Receptor (Rat).
• Immuno application
  immuno-histo-chemistry
• Antibody advice
  Calcium-Sensing Receptor antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 5 ug/mL.
• Suspention pH azide
  PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide.
• Keep at
  Store Calcium-Sensing Receptor antibody at 4 grades C, Avoid Freezing
• Works with
  Human, Rat
• Omim nr
  1168781
• Ncbi nr
  P41180
• Vial with antibody
  in solution
• NCBI GENE nr
  846
• GENE symbol
  CASR
• Antigene name
  calcium-sensing receptor
• Source
  Homo sapiens
• Protein nr
  P41180
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Calcium-Sensing   Receptor  
• Gene symbol
  CASR, VN2R1P
• Short name
  anti-Calcium-Sensing Receptor Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toCalcium-Sensing Receptor (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:1514
• Gene
  CASR
• Long gene name
  calcium sensing receptor
• Synonyms gene
  • HHC
  • HHC1
• Synonyms gene name
  • hypocalciuric hypercalcemia 1
  • calcium-sensing receptor
• Synonyms
  • FHH
  • NSHPT
  • GPRC2A
• Synonyms name
  • severe neonatal hyperparathyroidism
• GenBank acession
  • U20760
• Locus
  3q13.33-q21.1
• Discovery year
  1992-12-04
• Entrez gene record
  846
• Pubmed identfication
  • 7677761
• RefSeq identity
  • NM_000388
• Classification
  • Calcium sensing receptors
• VEGA ID
  OTTHUMG00000159491
• Locus Specific Databases
  • CASRdb Calcium Sensing Receptor Locus Mutation Database

Gene info

• Identity
  HGNC:30344
• Gene
  VN2R1P
• Long gene name
  vomeronasal 2 receptor 1 pseudogene
• Synonyms gene
  • CASRL1
• Synonyms gene name
  • calcium-sensing receptor like 1
• Synonyms
  • GPRC2B
• GenBank acession
  • AB065664
• Locus
  3q25.31
• Discovery year
  2005-05-10
• Entrez gene record
  344760
• RefSeq identity
  • NG_006066
• Classification
  • Vomeronasal receptors
• VEGA ID
  OTTHUMG00000154694

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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