Anti-beta Amyloid 1-42 (Polyclonal), ALEXA Fluor 594

• Catalog number
  GENTObs-0107R-A594
• Price
  Please ask
• Size
  100 microliters

• Type
  Conjugated Primary Antibody
• Conjugated with
  ALEXA FLUOR® 594
• Host organism
  Rabbit (Oryctolagus cuniculus)
• Target Protein Peptide
  beta Amyloid 1-42
• Specificity
  This antibody reacts specifically with beta Amyloid 1-42
• Modification
  No modification has been applied to this antibody
• Modification site
  None
• Clonality
  Polyclonal Antibody
• Clone
  Polyclonal Antibodies
• Concentration
  1ug per 1ul
• Subcellular locations
  Extracellular, Secreted
• Antigen Source
  KLH conjugated synthetic peptide of human beta-Amyloid(1-42)
• Gene ID
  351
• Swiss Prot
  P05067
• Applications
  IF(IHC-P)
• Applications with corresponding dilutions
  IF(IHC-P)(1:50-200)
• Cross reactive species
  Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
• Cross Reactive Species details
  No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
• Background information
  The cerebral and vascular plaques associated with Alzheimer's disease are mainly composed of Amyloid beta peptides. beta Amyloid is derived from cleavage of the Amyloid precursor protein and varies in length from 39 to 43 amino acids. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides result from cleavage of Amyloid precursor protein after residues 40, 42, and 43, respectively. The cleavage takes place by gamma-secretase during the last Amyloid precursor protein processing step. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides are major constituents of the plaques and tangles that occur in Alzheimer's disease. beta Amyloid and peptides have been developed as tools for elucidating the biology of Alzheimer's disease.
• Purification method
  Purified by Protein A.
• Storage
  Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
• Excitation emission
  590nm/617nm
• Synonyms
  AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma; Amyloid beta A4 protein; APP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; PreA4; Protease nexin-II; A4
• Also known as
  beta Amyloid 1-42 Polyclonal Antibody
• Other name
  Anti-beta Amyloid 1-42 Polyclonal
• Advisory
  Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
• Properties
  For facs or microscopy Alexa 1 conjugate.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

• Gene target
  beta   Amyloid   1-42  
• Gene symbol
  SNORD115-42, IGLVI-42, IGHV3-42, IGKV1D-42, RNU6-42P, DSCAM, NFX1, KIR2DL1, IGHVII-1-1, MIR1-1
• Short name
  Anti-beta Amyloid 1-42
• Technique
  Polyclonal, anti-, anti, antibody to, antibodies, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  beta Amyloid 1-42 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
• Alternative technique
  polyclonals, antibodies

Gene info

• Identity
  HGNC:33061
• Gene
  SNORD115-42
• Long gene name
  small nucleolar RNA, C/D box 115-42
• Synonyms
  • HBII-52-42
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033816
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003357.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:5936
• Gene
  IGLVI-42
• Long gene name
  immunoglobulin lambda variable (I)-42 (pseudogene)
• Synonyms gene name
  • immunoglobulin lambda variable (I)-42
  • immunoglobulin lambda variable (I)-42 pseudogene
• Synonyms
  • IGLV(I)-42
• GenBank acession
  • X14613
• Locus
  22q11.22
• Discovery year
  2000-05-08
• Entrez gene record
  28767
• RefSeq identity
  • NG_000002
• Classification
  • Immunoglobulin lambda locus at 22q11.2
• VEGA ID
  OTTHUMG00000151043

Gene info

• Identity
  HGNC:5603
• Gene
  IGHV3-42
• Long gene name
  immunoglobulin heavy variable 3-42 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable 3-42
  • immunoglobulin heavy variable 3-42 pseudogene
• GenBank acession
  • M99671
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28427
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152081

Gene info

• Identity
  HGNC:5757
• Gene
  IGKV1D-42
• Long gene name
  immunoglobulin kappa variable 1D-42 (non-functional)
• Synonyms gene name
  • immunoglobulin kappa variable 1D-42
• GenBank acession
  • X72816
• Locus
  2p11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28892
• RefSeq identity
  • NG_000833
• Classification
  • Immunoglobulin kappa locus at 2p11.2
• VEGA ID
  OTTHUMG00000151573

Gene info

• Identity
  HGNC:34286
• Gene
  RNU6-42P
• Long gene name
  RNA, U6 small nuclear 42, pseudogene
• Synonyms gene
  • RNU6-42
• Synonyms gene name
  • RNA, U6 small nuclear 42
• Locus
  3q29
• Discovery year
  2008-06-10
• Entrez gene record
  100302742
• RefSeq identity
  • NR_028373

Gene info

• Identity
  HGNC:3039
• Gene
  DSCAM
• Long gene name
  DS cell adhesion molecule
• Synonyms gene name
  • Down syndrome cell adhesion molecule
• Synonyms
  • CHD2-42
  • CHD2-52
• GenBank acession
  • AF023449
• Locus
  21q22.2
• Discovery year
  1998-06-10
• Entrez gene record
  1826
• Pubmed identfication
  • 9426258
• RefSeq identity
  • NM_001389
• Classification
  • Ig-like cell adhesion molecule family
  • I-set domain containing
  • Fibronectin type III domain containing
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000086732

Gene info

• Identity
  HGNC:7803
• Gene
  NFX1
• Long gene name
  nuclear transcription factor, X-box binding 1
• Synonyms
  • NFX2
  • MGC20369
  • Tex42
  • TEG-42
• GenBank acession
  • U19759
• Locus
  9p12
• Discovery year
  1998-05-26
• Pubmed identfication
  • 7964459
  • 2511169
  • 12047746
• Classification
  • PHD finger proteins
  • Ring finger proteins
• VEGA ID
  OTTHUMG00000019772

Gene info

• Identity
  HGNC:6329
• Gene
  KIR2DL1
• Long gene name
  killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1
• Synonyms gene name
  • killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
• Synonyms
  • cl-42
  • nkat1
  • 47.11
  • p58.1
  • CD158A
• GenBank acession
  • L41267
• Locus
  19q13.42
• Discovery year
  1997-11-14
• Entrez gene record
  3802
• Pubmed identfication
  • 7749980
  • 7716543
• RefSeq identity
  • NM_014218
• Classification
  • Killer cell immunoglobulin like receptors
  • CD molecules
• VEGA ID
  OTTHUMG00000065885
• Locus Specific Databases
  • IPD-KIR Database

Gene info

• Identity
  HGNC:5670
• Gene
  IGHVII-1-1
• Long gene name
  immunoglobulin heavy variable (II)-1-1 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable (II)-1-1
  • immunoglobulin heavy variable (II)-1-1 pseudogene
• Synonyms
  • IGHV(II)-1-1
• GenBank acession
  • AB019441
• Locus
  14q32.33
• Discovery year
  2000-04-17
• Entrez gene record
  28377
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152325

Gene info

• Identity
  HGNC:31499
• Gene
  MIR1-1
• Long gene name
  microRNA 1-1
• Synonyms gene
  • MIRN1-1
• Synonyms
  • hsa-mir-1-1
• Locus
  20q13.33
• Discovery year
  2004-04-23
• Entrez gene record
  406904
• RefSeq identity
  • NR_029780
• Classification
  • MicroRNA MIR1/206 family

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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