BACE Antibody (CT)

  • Catalog number
    5051-100
  • Price
    Please ask
  • Size
    100 µg
  • Antibody Target
    BACE
  • Target Alternative Name
    BACE (CT). Asp2
  • Antibody Type
    Polyclonal
  • Species Reactivities
    Human, mouse
  • Immunogen Sequence
    A peptide corresponding to 17 amino acids at the CT of human BACE.
  • Accession
    P56817
  • Gene Id
    23621
  • Appearance
    Colorless liquid
  • Form
    Liquid
  • Concentration
    1 mg/ml
  • Formulation
    100 µg (1 mg/ml) in 1X PBS containing 0.02% sodium azide.
  • Purification
    Ion exchange chromatography.
  • Application
    Western blot, Immunohistochemistry, ELISA
  • Positive Control
    Human brain tissue lysate and mouse 3T3 cell lysate
  • Application And Usages
    Immunocytochemistry: 10 μg/ml, Western Blot: 0.5 – 1 μg/ml; ELISA. However, the optimal conditions should be determined individually.
  • Description
    Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by two proteases. APP is first cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide, which is deposited in the brains of all suffers of Alzheimer's disease. The long-soμght beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.
  • Storage Condition
    -20 °C
  • Shipping Condition
    gel pack
  • Shelf Life
    12 months
  • Usage
    For Research Use Only! Not to be used in humans.
  • Handling
    The antibody solution should be gently mixed before use.
  • Western Blot Verified
    Verified
  • Immunocytochemistry Verified
    Verified
  • Immunofluorescence Verified
    Not Verified
  • Immunoprecipitation Verified
    Not Verified
  • FACS Verified
    Not Verified
  • ELISA Verified
    Verified
  • ChIP Verified
    Not Verified
  • Flow Cytometry Verified
    Not Verified
  • Properties
    If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
    anticorps
  • Gene target
    BACE  
  • Gene symbol
    BACE1
  • Short name
    BACE Antibody (CT)
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Isotype
    Rabbit IgG1
  • Alternative name
    BACE (antibody to-) (CT)
  • Alternative technique
    antibodies
Gene info
  • Identity
  • Gene
  • Long gene name
    beta-secretase 1
  • Synonyms gene
  • Synonyms gene name
    • beta-site APP-cleaving enzyme
    • beta-site APP-cleaving enzyme 1
  • GenBank acession
  • Locus
  • Discovery year
    1999-10-29
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Peptidase family A1
  • VEGA ID
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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