recMAb™ Anti-ATRX/RAD54 Antibody
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Catalog number
A2216-100
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Price
Please ask
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Size
100 µg
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Antibody Target
ATRX
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Target Alternative Name
JMS, XH2, XNP, MRX52, RAD54, RAD54L, ZNF-HX, MRXHF1, SFM1, SHS, ATR2
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Antibody Type
Monoclonal
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Clone
ATRX/2900R
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Species Reactivities
Human
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Immunogen Sequence
Recombinant human ATRX protein
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Accession
P46100
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Gene Id
546
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Appearance
Colorless liquid
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Form
Liquid
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Concentration
1 mg/ml
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Formulation
In 10 mM PBS
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Purification
Protein A/G purified
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Application
Immunohistochemistry (IHC)
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Application And Usages
IHC (1-2 µg/ml)
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Description
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
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Storage Condition
-20ºC
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Shipping Condition
Gel Pack
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Shelf Life
12 months
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Usage
For Research Use Only! Not to be used in humans.
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Handling
The antibody solution should be gently mixed before use.
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Additional description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
ATRX
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Short name
recMAb™ Anti-ATRX/RAD54 Antibody
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Isotype
IgG
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Alternative name
recMAb™ Antibody toATRX/RAD54 (antibody to-)
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Alternative technique
antibodies
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Gene info
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Identity
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Gene
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Long gene name
ATRX chromatin remodeler
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Synonyms gene
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Synonyms gene name
- alpha thalassemia/mental retardation syndrome X-linked (RAD54 (S. cerevisiae) homolog)
- Juberg-Marsidi syndrome
- mental retardation, X-linked 52
- alpha thalassemia/mental retardation syndrome X-linked
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
1992-11-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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