Smo Antagonist, SA10

• Catalog number
  2159-2
• Price
  Please ask
• Size
  2 mg

• Alternative_name
  4-((Benzo[c][1,2,5]thiadiazole-4-sulfonamido)methyl-N-(3-phenylpropyl)cyclohexanecarboxamide
• Description
  SA10 inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 5 µM). However, unlike SA1 and SA9, Smo antagonist SA10 does not directly bind to Smo. Inhibits the localization o Smo to cilia. Also treatment of Ptch1-/- MEFs with SA10 suppresses the β-galactosidase activity (IC₅₀ = 11.0 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₃H₂₈N₄O₃S₂
• Molecular Weight
  472.62
• Cell Permeable
  Yes
• Purity
  ≥95% by NMR
• Solubilities
  DMSO
• Handling
  Protect from air and moisture
• Tag Line
  A Hedgehog (Hh) signaling pathway antagonist
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24months
• SMILES
  N/A
• InChi
  N/A
• InChi Key
  N/A
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  The antagonist receptor ligand binding will be in contrast with agonist activity. Biovision produces more antagonist and receptor related products as 1.

• Gene target
  Smo   Antagonist   SA10  
• Short name
  Smo Antagonist, SA10
• Alternative name
  smoothened, frizzled family receptor Antagonist, SA10
• Alternative to gene target
  smoothened, frizzled family receptor, FZD11 and Gx and SMOH, SMO and IDBG-40669 and ENSG00000128602 and 6608, Wnt-activated receptor activity, Cell surfaces, Smo and IDBG-132261 and ENSMUSG00000001761 and 319757, SMO and IDBG-635317 and ENSBTAG00000013287 and 539308

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