Anti- Alpha Glucosidase (Polyclonal), ALEXA Fluor 594

• Catalog number
  GENTObs-13254R-A594
• Price
  Please ask
• Size
  100 microliters

• Type
  Conjugated Primary Antibody
• Conjugated with
  ALEXA FLUOR® 594
• Host organism
  Rabbit (Oryctolagus cuniculus)
• Target Protein Peptide
  GAA
• Specificity
  This antibody reacts specifically with Alpha Glucosidase
• Modification
  No modification has been applied to this antibody
• Modification site
  None
• Clonality
  Polyclonal Antibody
• Clone
  Polyclonal Antibodies
• Concentration
  1ug per 1ul
• Subcellular locations
  N/A
• Antigen Source
  KLH conjugated synthetic peptide derived from human GAA/Glucosidase alpha
• Gene ID
  2548
• Swiss Prot
  N/A
• Applications
  IF(IHC-P)
• Applications with corresponding dilutions
  IF(IHC-P)(1:50-200)
• Cross reactive species
  Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
• Cross Reactive Species details
  No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
• Background information
  This gene encodes acid alpha-glucosidase, which is essential for the degradation of glycogen to glucose in lysosomes. Different forms of acid alpha-glucosidase are obtained by proteolytic processing. Defects in this gene are the cause of glycogen storage disease II, also known as Pompe's disease, which is an autosomal recessive disorder with a broad clinical spectrum. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
• Purification method
  Purified by Protein A.
• Storage
  Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
• Excitation emission
  590nm/617nm
• Synonyms
  70 kDa lysosomal alpha-glucosidase; Acid alpha glucosidase; Acid maltase; Aglucosidase alfa; Alpha glucosidase; GAA; Glucosidase alpha acid Pompe disease glycogen storage disease type II; Glucosidase alpha acid; Glucosidase alpha; LYAG; LYAG_HUMAN; Lysosomal alpha glucosidase.
• Also known as
  Alpha Glucosidase Polyclonal Antibody
• Other name
  Anti- Alpha Glucosidase Polyclonal
• Advisory
  Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
• Properties
  For facs or microscopy Alexa 1 conjugate.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• Description
  The Anti- Alpha Glucosidase is a α- or alpha protein sometimes glycoprotein present in blood. This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

• Gene target
  Alpha   Glucosidase  
• Gene symbol
  SI, GANAB, GAA
• Short name
  Anti- Alpha Glucosidase
• Technique
  Polyclonal, anti, antibody to, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  Alpha Glucosidase Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
• Alternative technique
  polyclonals, antibodies

Gene info

• Identity
  HGNC:10856
• Gene
  SI
• Long gene name
  sucrase-isomaltase
• Synonyms gene name
  • sucrase-isomaltase (alpha-glucosidase)
• Synonyms name
  • Oligosaccharide alpha-1,6-glucosidase
  • Oligo-1,6-glucosidase
  • alpha-glucosidase
  • Alpha-methylglucosidase
• GenBank acession
  • X63597
• Locus
  3q26.1
• Discovery year
  1986-01-01
• Entrez gene record
  6476
• Pubmed identfication
  • 2962903
  • 1353958
• RefSeq identity
  • NM_001041
• Classification
  • Glycoside hydrolase family 31
• VEGA ID
  OTTHUMG00000158065

Gene info

• Identity
  HGNC:4138
• Gene
  GANAB
• Long gene name
  glucosidase II alpha subunit
• Synonyms gene name
  • glucosidase, alpha; neutral AB
• Synonyms
  • GluII
  • G2AN
  • KIAA0088
  • GIIA
• Synonyms name
  • neutral alpha-glucosidase AB
• GenBank acession
  • AF144074
• Locus
  11q12.3
• Discovery year
  2001-06-22
• Entrez gene record
  23193
• Pubmed identfication
  • 6342981
  • 3881423
  • 10764838
• RefSeq identity
  • NM_198334
• Classification
  • Glycoside hydrolase family 31
• VEGA ID
  OTTHUMG00000167696

Gene info

• Identity
  HGNC:4065
• Gene
  GAA
• Long gene name
  alpha glucosidase
• Synonyms gene name
  • glucosidase, alpha; acid
  • glucosidase alpha, acid
• Synonyms name
  • Pompe disease
  • glycogen storage disease type II
• Locus
  17q25.3
• Discovery year
  1986-01-01
• Entrez gene record
  2548
• Classification
  • Glycoside hydrolase family 31
• VEGA ID
  OTTHUMG00000177537
• Locus Specific Databases
  • GAA - Pompe disease (glycogen storage disease type II)
  • Global Variome shared LOVD
  • LRG_673

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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