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Gene info
Bnip3L Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and Bim, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bnip3L, Bnip3alpha, and Nix (for Nip3-like protein X). Bnip3L/Bnip3alpha/Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis. Bnip3L interacts with and overcomes suppresses by Bcl-2 and Bcl-xL. Bnip3L is localized in mitochondria. The messenger RNA of Bnip3L is ubiquitously expressed in human tissues. Bnip3L and Bnip3 form a new subfamily of the pro-apoptotic mitochondrial proteins.
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Gene names
Bnip3L Antibody: NIX, BNIP3a, BNIP3A, BNIP3H, NIX, Adenovirus E1B19K-binding protein B5, NIP3L
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Antibodie s label
unlabelled serum
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Purity
Bnip3L Antibody is affinity chromatography purified via peptide column.
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Ab raised in
Rabbit
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Type
Polyclonal
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Immunoglobulin
IgG
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Antigen
Bnip3L antibody was made against a 16 amino acid peptide near the center of human Bnip3L.
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Immuno application
ELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence
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Antibody advice
Bnip3L antibody can be used for detection of Bnip3L by Western blot at 1 ug/mL. The approximate 40 kDa top band represents monomer of Bnip3L (4). Antibody can also be used for immunohistochemistry starting at 2 ug/mL. For immunofluorescence start at 10 ug/mL.
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Suspention pH azide
Bnip3L Antibody is supplied in PBS containing 0.02% sodium azide.
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Keep at
Bnip3L antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Works with
Human
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Omim nr
4138825
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Ncbi nr
AF067396
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KDa
40 kDa
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Vial with antibody
in solution
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NCBI GENE nr
665
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GENE symbol
BNIP3L
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Antigene name
BCL2/adenovirus E1B 19kDa interacting protein 3-like
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Source
Homo sapiens
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Protein nr
O60238
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
BNIP3L
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Short name
anti-Bnip3L Antibody
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative name
Antibody toBCL2/adenovirus E1B 19kDa interacting protein 3-like (antibody to-)
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Alternative technique
antibodies
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Alternative to gene target
BCL2/adenovirus E1B 19kDa interacting protein 3-like, BNIP3a and NIX, BNIP3L and IDBG-13074 and ENSG00000104765 and 665, protein heterodimerization activity, nuclei, Bnip3l and IDBG-175760 and ENSMUSG00000022051 and 100043324,102641641,12177, BNIP3L and IDBG-635626 and ENSBTAG00000021307 and 534615
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