anti-Aak1 Antibody

• Catalog number
  4841
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  Aak1 Antibody: AP2-associated protein kinase 1 (Aak1) is a member of the Ark1/Prk1 subfamily of Ser/Thr protein kinases that are thought to regulate endocytosis by phosphorylating the accessory endocytic components. Aak1 interacts with and phosphorylates the mu2 subunit of the AP-2 complex, which promotes binding of the AP-2 to tyrosine based (Yxxphi) internalization motif-containing receptors and subsequent receptor endocytosis. At least two isoforms of Aak1 are known to exist; the longer isoform contains an extended carboxy-terminus that contains an additional clathrin-binding domain. Overexpression of this long isoform or Aak1 depletion by RNA interference impairs transferrin recycling from the early/sorting endosome, suggesting that Aak1 functions at multiple steps of the endosomal pathway by regulating transferrin internalization and its recycling back to the plasma membrane.
• Gene names
  Aak1 Antibody: KIAA1048, AP2-associated protein kinase 1, Adaptor-associated kinase 1
• Antibodie s label
  unlabelled serum
• Purity
  Aak1 Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Antigen
  Aak1 antibody was made against a 20 amino acid synthetic peptide near the amino terminus of the human Aak1.
• Immuno application
  ELISA, Western Blot, immuno-cyto-chemistry, immuno fluorescence
• Antibody advice
  Aak1 antibody can be used for detection of Aak1 by Western blot at 1 - 2 ug/mL. Antibody can also be used for immunocytochemistry starting at 5 ug/mL. For immunofluorescence start at 20 ug/mL.
• Suspention pH azide
  Aak1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  Aak1 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human, Mouse, Rat
• Omim nr
  148277037
• Ncbi nr
  NP_055726
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  22848
• GENE symbol
  AAK1
• Antigene name
  AP2 associated kinase 1
• Source
  Homo sapiens
• Protein nr
  Q2M2I8
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Aak1  
• Gene symbol
  AAK1
• Short name
  anti-Aak1 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toAak1 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:19679
• Gene
  AAK1
• Long gene name
  AP2 associated kinase 1
• Synonyms
  • KIAA1048
  • DKFZp686K16132
• GenBank acession
  • AB028971
• Locus
  2p13.3
• Discovery year
  2003-07-21
• Entrez gene record
  22848
• Pubmed identfication
  • 11877461
  • 12471243
• RefSeq identity
  • NM_014911
• Classification
  • Small nucleolar RNA protein coding host genes
• VEGA ID
  OTTHUMG00000129648

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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