Anti-5HT7 Receptor/SR-7 (Polyclonal), ALEXA Fluor 594

• Catalog number
  GENTObs-12056R-A594
• Price
  Please ask
• Size
  100 microliters

• Type
  Conjugated Primary Antibody
• Conjugated with
  ALEXA FLUOR® 594
• Host organism
  Rabbit (Oryctolagus cuniculus)
• Target Protein Peptide
  5HT7 Receptor/SR-7
• Specificity
  This antibody reacts specifically with 5HT7 Receptor/SR-7
• Modification
  No modification has been applied to this antibody
• Modification site
  None
• Clonality
  Polyclonal Antibody
• Clone
  Polyclonal Antibodies
• Concentration
  1ug per 1ul
• Subcellular locations
  Extracellular
• Antigen Source
  KLH conjugated synthetic peptide derived from human 5HT7 Receptor/SR-7
• Gene ID
  N/A
• Swiss Prot
  N/A
• Applications
  FCM, IF(IHC-P)
• Applications with corresponding dilutions
  FCM(1:20-100), IF(IHC-P)(1:50-200)
• Cross reactive species
  Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
• Cross Reactive Species details
  No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
• Background information
  Serotonin (also designated 5-hydroxytryptamine or 5-HT) is a molecule that functions as a neurotransmitter, a hormone and a mitogen, and it is predominantly expressed in the gut, platelets and central nervous system (CNS). In the CNS, serotonin modulates several processes, including anxiety, sleep, appetite, behavior and drug abuse. In platelets and gut, serotonin plays a major role in cardiovascular function and motility of the gastrointestinal tract, respectively. Serotonin mediates its effects through several of G protein coupled receptors, designated 5-HT receptors or alternatively SR receptors. SR-3 is a ligand-gated ion channel, whereas all other known serotonin receptor subtypes are G protein-coupled receptors. SR-4 mediates widespread effects in central and peripheral nervous systems. SR-7 belongs to the superfamily of G protein-coupled receptors. The gene which encodes SR-7 maps to human chromosome 10q21-q24.
• Purification method
  Purified by Protein A.
• Storage
  Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
• Excitation emission
  590nm/617nm
• Synonyms
  HT 7; 5 HT X; 5 hydroxytryptamine serotonin receptor 7 adenylate cyclase coupled; 5 hydroxytryptamine serotonin receptor 7; 5 hydroxytryptamine receptor 7; 5-HT-7; 5-HT-X; 5-HT7; 5-hydroxytryptamine receptor 7; 5HT7; 5HT7R_HUMAN; HTR7; Serotonin 5 HT 7 receptor; Serotonin receptor 7.
• Also known as
  5HT7 Receptor/SR-7 Polyclonal Antibody
• Other name
  Anti-5HT7 Receptor/SR-7 Polyclonal
• Advisory
  Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
• Properties
  For facs or microscopy Alexa 1 conjugate.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

• Gene target
  5HT7   Receptor/SR-7  
• Gene symbol
  MSR1, MEGF10, MARCO, PIRC34, PIRC33, SRPRB, SIGMAR1, SNCG, PIRC32, SNORD114-7
• Short name
  Anti-5HT7 Receptor/SR-7
• Technique
  Polyclonal, anti-, anti, antibody to, antibodies, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  5HT7 Receptor/SR-7 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
• Alternative technique
  polyclonals, antibodies

Gene info

• Identity
  HGNC:7376
• Gene
  MSR1
• Long gene name
  macrophage scavenger receptor 1
• Synonyms
  • SCARA1
  • CD204
  • SR-AI
  • SR-AII
  • SR-AIII
  • SR-A
• GenBank acession
  • D13263
• Locus
  8p22
• Discovery year
  1991-08-07
• Pubmed identfication
  • 2251254
• Classification
  • CD molecules
  • Scavenger receptors
  • Scavenger receptor cysteine rich domain containing
• VEGA ID
  OTTHUMG00000094809

Gene info

• Identity
  HGNC:29634
• Gene
  MEGF10
• Long gene name
  multiple EGF like domains 10
• Synonyms gene name
  • multiple EGF-like-domains 10
• Synonyms
  • KIAA1780
  • SR-F3
• GenBank acession
  • AK021631
• Locus
  5q23.2
• Discovery year
  2006-03-31
• Entrez gene record
  84466
• Pubmed identfication
  • 11347906
  • 27170117
• RefSeq identity
  • NM_032446
• Classification
  • Scavenger receptors
• VEGA ID
  OTTHUMG00000128984

Gene info

• Identity
  HGNC:6895
• Gene
  MARCO
• Long gene name
  macrophage receptor with collagenous structure
• Synonyms
  • SCARA2
  • SR-A6
• Synonyms name
  • scavenger receptor class A, member 2
• GenBank acession
  • AF035819
• Locus
  2q14.2
• Discovery year
  1998-11-26
• Entrez gene record
  8685
• Pubmed identfication
  • 9468508
  • 7867067
  • 10331948
• RefSeq identity
  • NM_006770
• Classification
  • Scavenger receptors
  • Scavenger receptor cysteine rich domain containing
• VEGA ID
  OTTHUMG00000131400

Gene info

• Identity
  HGNC:37538
• Gene
  PIRC34
• Long gene name
  piwi-interacting RNA cluster 34
• Locus
  7
• Discovery year
  2009-11-05
• Entrez gene record
  100313890
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37537
• Gene
  PIRC33
• Long gene name
  piwi-interacting RNA cluster 33
• Locus
  7
• Discovery year
  2009-11-05
• Entrez gene record
  100313854
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:24085
• Gene
  SRPRB
• Long gene name
  SRP receptor subunit beta
• Synonyms gene name
  • signal recognition particle receptor, B subunit
• Synonyms
  • APMCF1
  • SR-beta
• GenBank acession
  • AK075531
• Locus
  3q22.1
• Discovery year
  2004-01-29
• Entrez gene record
  58477
• Pubmed identfication
  • 7844142
  • 10859309
• VEGA ID
  OTTHUMG00000159753

Gene info

• Identity
  HGNC:8157
• Gene
  SIGMAR1
• Long gene name
  sigma non-opioid intracellular receptor 1
• Synonyms gene
  • OPRS1
• Synonyms gene name
  • opioid receptor, sigma 1
• Synonyms
  • SR-BP1
• GenBank acession
  • BC004899
• Locus
  9p13.3
• Discovery year
  1993-03-11
• Entrez gene record
  10280
• Pubmed identfication
  • 8954936
  • 9453537
• RefSeq identity
  • NM_005866
• VEGA ID
  OTTHUMG00000019829

Gene info

• Identity
  HGNC:11141
• Gene
  SNCG
• Long gene name
  synuclein gamma
• Synonyms
  • BCSG1
  • SR
  • persyn
• Synonyms name
  • synoretin
  • breast cancer-specific gene 1
  • ɣ-synuclein
• GenBank acession
  • AF044311
• Locus
  10q23.2
• Discovery year
  1998-04-07
• Entrez gene record
  6623
• Pubmed identfication
  • 9044857
  • 9700196
• VEGA ID
  OTTHUMG00000018656
• Locus Specific Databases
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database

Gene info

• Identity
  HGNC:37536
• Gene
  PIRC32
• Long gene name
  piwi-interacting RNA cluster 32
• Locus
  7
• Discovery year
  2009-11-05
• Entrez gene record
  100313811
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:32995
• Gene
  SNORD114-7
• Long gene name
  small nucleolar RNA, C/D box 114-7
• Synonyms
  • 14q(II-7)
• Locus
  14q32.31
• Discovery year
  2006-09-26
• Entrez gene record
  767583
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003199.1
• Classification
  • Small nucleolar RNAs, C/D box

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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