Altiratinib for cell activation

Altiratinib for cell activation is available 2 times from Biovision labs

9563-5 | Altiratinib for cell activationsize: 5 mg | 217.06 USD

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9563-25 | Altiratinib for cell activationsize: 25 mg | 686.2 USD

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  • Description
    Altiratinib is a selective and highly potent inhibitor of MET, TIE2, VEGFR2 and TRK kinases with potential anticancer activity. It effectively reduces tumor burden in vivo and blocks c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro. Through its balanced inhibitory potency versus MET, TIE2, and VEGFR2, altiratinib inhibits three major evasive (re)vascularization and resistance pathways (HGF, ANG, and VEGF) and blocks tumor invasion and metastasis. Displays blood-brain barrier penetration.
  • Peptide sequence
    N/A
  • CAS number
    1345847-93-9
  • Molecular weight
    510.46
  • Category
    Biochemicals
  • Other name
    N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-2,5-difluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; DCC-2701
  • Molecular formula
    C₂₆H₂₁F₃N₄O₄
  • Physical appearance
    White to off-white solid
  • Supplied with
    N/A
  • Is this a salt?
    No
  • Is it cell-permeable?
    Yes
  • Purification
    ≥98% by HPLC
  • Reconstitute instructions
    DMSO (>30 mg/ml)
  • Storage condition
    -20°C
  • Shipping condition
    gel pack
  • Maximum time for storage
    36 months
  • Storage instructions
    Protect from air and light
  • Additional description
    For cells, cell lines and tissues in culture till half confluency.
  • Gene target
  • Short name
    Altiratinib for activation
  • Technique
    activation
  • Alternative name
    Altiratinib to measure cellular activation
  • Tissue
    cell
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