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Target antigen
alpha 2a Adrenergic Receptor
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
mouse Theoretical reactivity:human, rat
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Analyses
WB
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Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human alpha 2a Adrenergic Receptor(213-228aa ILVYVRIYQIAKRRTR), identical to the related mouse and rat sequences.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the alpha 2a Adrenergic Receptor Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The alpha 2a Adrenergic Receptor Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
The alpha-2A adrenergic receptor, also known as ADRA2A denotes the human gene encoding it. This gene is mapped to 10q25.2. Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
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Related articles
1. Philipp, M., Brede, M. E., Hadamek, K., Gessler, M., Lohse, M. J., Hein, L. Placental alpha-2-adrenoceptors control vascular development at the interface between mother and embryo. Nature Genet. 31: 311-315, 2002. 2. Rosengren, A. H., Jokubka, R., Tojjar, D., Granhall, C., Hansson, O., Li, D.-Q., Nagaraj, V., Reinbothe, T. M., Tuncel, J., Eliasson, L., Groop, L., Rorsman, P., Salehi, A., Lyssenko, V., Luthman, H., Renstrom, E. Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes. Science 327: 217-220, 2010.
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Gene Name
ADRA2A
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Protein Name
Alpha-2A adrenergic receptor
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Gene Full Name
adrenoceptor alpha 2A
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Synonyms
ADA2A_HUMAN antibody|ADRA2 antibody|ADRA2A antibody|ADRA2R antibody|ADRAR antibody|Adrenergic alpha 2A receptor antibody|Alpha 2 adrenergic receptor subtype C10 antibody|Alpha 2A adrenergic receptor antibody|Alpha 2AAR subtype C10 antibody|Alpha-2 adrenergic receptor subtype C10 antibody|alpha-2-adrenergic receptor, platelet type antibody|Alpha-2A adrenergic receptor antibody|Alpha-2A adrenoceptor antibody|Alpha-2A adrenoreceptor antibody|Alpha-2AAR antibody|ALPHA2AAR antibody|OTTHUMP00000058849 antibody|ZNF32 antibody
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Uniprot ID
P08913
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Description
The alpha 2a Adrenergic Receptor Antibody is a α- or alpha protein sometimes glycoprotein present in blood. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
