AG 494,EGFR kinase inhibitor

Research Area s

Cell Signaling , Cancer , Apoptosis , Cancer Growth Inhibitors , Tyrosine Kinase Inhibitors
Category

Small Molecules
Product Type

Inhibitor
CAS No

133550-35-3
MolecularFormula

C16H12N2O3
Molecular Weight

280.3
Purity

≥98% (TLC)
Solubility

Soluble in DMSO (25 mg/ml) or 100% ethanol (25 mg/ml)
Appearance

Yellow solid
Storage Temperature

-20°C
Shipping Temperature

Shipped Ambient
Description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Gene target

494 EGFR kinase inhibitor
Gene symbol

EGFR-AS1, EGILA, EGFR, RHBDF1
Short name

AG 494 EGFR kinase inhibitor
Alternative name

AG 494,epidermal growth factor receptor phosphorylation catalyst suppressor
Alternative to gene target

epidermal growth factor receptor, ERBB and ERBB1 and HER1 and mENA and PIG61, EGFR and IDBG-16933 and ENSG00000146648 and 1956, transferase activity, nuclei, Egfr and IDBG-151194 and ENSMUSG00000020122 and 13649, EGFR and IDBG-644035 and ENSBTAG00000011628 and 407217

Identity

HGNC:3236
Gene

EGFR
Long gene name

epidermal growth factor receptor
Synonyms gene
- ERBB
Synonyms gene name
- epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)
Synonyms
- ERBB1
- ERRP
Synonyms name
- erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian)
- erb-b2 receptor tyrosine kinase 1
Locus

7p11.2
Discovery year

1986-01-01
Entrez gene record

1956
Pubmed identfication
- 1505215
RefSeq identity
- NM_005228
Classification
- Erb-b2 receptor tyrosine kinases
VEGA ID

OTTHUMG00000023661
Locus Specific Databases
- LRG_304

Identity

HGNC:20561
Gene

RHBDF1
Long gene name

rhomboid 5 homolog 1
Synonyms gene
- C16orf8
Synonyms gene name
- chromosome 16 open reading frame 8
- rhomboid family 1 (Drosophila)
- rhomboid 5 homolog 1 (Drosophila)
Synonyms
- EGFR-RS
- FLJ2235
- Dist1
- iRhom1
GenBank acession
- BC014425
Locus

16p13.3
Discovery year

2003-04-07
Entrez gene record

64285
Pubmed identfication
- 8318735
- 15965977
RefSeq identity
- NM_022450
Classification
- Rhomboid family
VEGA ID

OTTHUMG00000060719