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Target antigen
ADAMTS2
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human, mouse, rat
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Analyses
WB,IHC-P,IHC-F
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Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human ADAMTS2(1189-1204aa KTRNQRIQELIDEMRK), different from the related rat and mouse sequences by three amino acids.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the ADAMTS2 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The ADAMTS2 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
ADAMTS2, A disintegrin and metalloproteinase with thrombospondin motifs 2, also known as procollagen I N-proteinase(PC I-NP), is an enzyme that in humans is encoded by the ADAMTS2 gene. The ADAMTS2 gene contains 22 exons. The human ADAMTS2 gene is mapped to chromosome 5q23-q24 by analysis of somatic cell hybrids. ADAMTS2 is responsible for processing several types of procollagen proteins. Procollagens are the precursors of collagens, the proteins that add strength and support to many body tissues. Specifically, this enzyme clips a short chain of amino acids off one end of the procollagen. This clipping step is necessary for collagen molecules to function normally and assemble into fibrils outside cells.
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Related articles
1. Colige, A., Nuytinck, L., Hausser, I., van Essen, A. J., Thiry, M., Herens, C., Ades, L. C., Malfait, F., De Paepe, A., Franck, P., Wolff, G., Oosterwijk, J. C., Smitt, J. H. S., Lapiere, C. M., Nusgens, B. V.Novel types of mutation responsible for the dermatosparactic type of Ehlers-Danlos syndrome (type VIIC) and common polymorphisms in the ADAMTS2 gene.J. Invest. Derm. 123: 656-663, 2004. 2. Hurskainen, T. L., Hirohata, S., Seldin, M. F., Apte, S. S.ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases: general features and genomic distribution of the ADAM-TS family.J. Biol. Chem. 274: 25555-25563, 1999.
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Gene Name
ADAMTS2
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Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 2(ADAM-TS 2/ADAM-TS2/ADAMTS-2)
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Gene Full Name
ADAM metallopeptidase with thrombospondin type 1 motif, 2
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Synonyms
A disintegrin and metalloproteinase with thrombospondin motifs 2 antibody|A disintegrin like and metalloprotease(reprolysin type) with thrombospondin type 1 motif 2 antibody|ADAM metallopeptidase with thrombospondin type 1 motif 2 antibody|ADAM TS 2 antibody|ADAM TS2 antibody|ADAM-TS 2 antibody|ADAM-TS2 antibody|ADAMTS 3 antibody|ADAMTS-2 antibody|ADAMTS2 antibody|ATS2_HUMAN antibody|EC 3.4.24.14 antibody|EDS VIIB antibody|EDS VIIC antibody|hPCPNI antibody|NPI antibody|PC I NP antibody|PC I-NP antibody|PCINP antibody|PCPNI antibody|pNPI antibody|Procollagen I N proteinase antibody|Procollagen I N-proteinase antibody|Procollagen I/II amino propeptide processing enzyme antibody|Procollagen I/II amino propeptide-processing enzyme antibody|Procollagen N endopeptidase antibody|Procollagen N-endopeptidase antibody
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Uniprot ID
O95450
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
