ADAMTS1 Antibody

• Catalog number
  R31182
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  ADAMTS1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the ADAMTS1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This ADAMTS1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P97857
• Purity
  Antigen affinity
• Description
  A Disintegrin-Like and Metalloproteinase with Thrombospondin Type 1 Motif, 1, also known as METH1, is an enzyme that in humans is encoded by the ADAMTS1 gene. ADAMTS is a family of proteins believed to be anchored to the extracellular matrix(ECM) through interactions with aggregan or other matrix components by one or more thrombospondin type 1 motifs. Scott(2000) mapped the gene to 21q21.2 based on sequence similarity between the ADAMTS1 sequence and a chromosome 21q21.2 clone. Kuno et al.(1997) found that mouse Adamts1 expression could be induced in vitro in colon adenocarcinoma cells by stimulation with the inflammatory cytokine interleukin 1-alpha, or in vivo in kidney and heart by intravenous administration of lipopolysaccharide. Vazquez et al.(1999) determined that ADAMTS1 disrupts angiogenesis in vivo and in vitro more efficiently than ADAMTS8, THBS1, or endostatin.
• Immunogen
  Amino acids 956-968 (KHYIDFCTLTQCS-mouse) were used as the immunogen for this ADAMTS1 antibody.
• Storage
  After reconstitution, the ADAMTS1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ADAMTS1  
• Gene symbol
  ADAMTS1
• Short name
  Anti-ADAMTS1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to ADAMTS1
• Alternative technique
  antibodies
• Alternative to gene target
  ADAM metallopeptidase with thrombospondin type 1 motif, 1, C3-C5 and METH1, ADAMTS1 and IDBG-1192 and ENSG00000154734 and 9510, zinc ion binding, Extracellular, Adamts1 and IDBG-173182 and ENSMUSG00000022893 and 11504, ADAMTS1 and IDBG-630287 and ENSBTAG00000000706 and 512171

Gene info

• Identity
  HGNC:217
• Gene
  ADAMTS1
• Long gene name
  ADAM metallopeptidase with thrombospondin type 1 motif 1
• Synonyms gene name
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1
• Synonyms
  • C3-C5
  • METH1
  • KIAA1346
• GenBank acession
  • AF060152
• Locus
  21q21.3
• Discovery year
  1998-11-19
• Entrez gene record
  9510
• Pubmed identfication
  • 10438512
• Classification
  • ADAM metallopeptidases with thrombospondin type 1 motif
• VEGA ID
  OTTHUMG00000078688

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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