ACTL6A Recombinant Protein
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Catalog number
XW-RP3003
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Price
Please ask
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Size
0.05 mg
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About recombinant protein
The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix.FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodelling (alteration of DNA-nucleosome topology). Required for maximal ATPase activity of SMARCA4/BRG1 and for association of the SMARCA4/BRG1 containing remodelling complex BAF with chromatin/nuclear matrix. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
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Other name of the recombinant
Arp4, ACTL6, BAF53A, INO80K, ARPN-BETA, BAF53, Actin-like protein 6A, 53 kDa BRG1-associated factor A
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Recombinant in
E. coli
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His tag on the recombinant protein
no His tag
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SEQUENCE
aa. 1-429
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Activity
not available
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Use of recmbinant
This recombinant protein can be used for WB, ELISA, MS.
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Protein is used in
E, WB, MS
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Suspention medium
10 mM Tris, pH 8.0, 0.1% Triton X-100, 0.002% NaN3
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Keep at
Store in working aliquots at -70˚C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
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Rec PROTEIN GI
4757718
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Accession nr
NP_004292
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KDa of reombinant
49.3 kDa (Calculated)
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Pureity
95%
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About
For research use only.
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Protein s origin
Human
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NCBI ID
86
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Gene name
actin-like 6A
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Source
Homo sapiens
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Uniprot
O96019
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Additional source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
ACTL6A
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Short name
ACTL6A Recombinant Protein
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Alternative name
ACTL6A Rec. Protein
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Alternative technique
rec
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Gene info
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Identity
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Gene
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Long gene name
actin like 6A
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
2004-07-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Actin related proteins
- INO80 complex
- PBAF complex
- BAF complex
- GBAF complex
- SRCAP complex
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VEGA ID
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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