Activin A Recombinant Protein
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Catalog number
40-213
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Price
Please ask
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Size
0.002 mg, 0.01 mg
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About recombinant protein
Activin A is a TGF-β family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin. Human Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues.
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Other name of the recombinant
JV18, MADH2, MADR2, JV18-1, hMAD-2, hSMAD2, Mothers against decapentaplegic homolog 2, MAD homolog 2
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Recombinant in
E. coli
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SEQUENCE
GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
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Activity
The ED50 was determined by its ability to inhibit the proliferation of murine MPC - 11 cells is ≤ 2.0 ng/mL, corresponding to a specific activity of ≥ 5 x 105 units/mg.
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Keep at
The lyophilized Activin A recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted Activin A is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing Activin A recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
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Rec PROTEIN GI
51173730
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Accession nr
NP_001003652.1
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Pureity
Greater than 97% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).
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About
This product is for research use only.
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Protein s origin
Human
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Vial
Lyophilized
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NCBI ID
4087
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Gene name
SMAD family member 2
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Source
Homo sapiens
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Uniprot
Q15796
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Additional source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
SMAD2
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Short name
Activin A Recombinant Protein
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Alternative name
Activin A Rec. Protein
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Alternative technique
rec
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Gene info
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Identity
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Gene
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Long gene name
SMAD family member 2
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Synonyms gene
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Synonyms gene name
- MAD, mothers against decapentaplegic homolog 2 (Drosophila)
- SMAD, mothers against DPP homolog 2 (Drosophila)
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Synonyms
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GenBank acession
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Locus
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Discovery year
1996-11-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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