Acetyl Lysine Antibody

• Catalog number
  bs-8850R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Acetyl Lysine Primary Polyclonal Antibody
• Also known as
  Acetyl Lysine PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Acetyl Lysine
• Specificity
  This is a highly specific antibody against Acetyl Lysine.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated acetyl Lysine
• Tested Applications
  WB
• Recommended dilutions
  WB(1:100-1000)
• Cross reactivity
  Others
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  In the nucleus, DNA is tightly packed into nucleosomes generating an environment which is highly repressive towards DNA processes such as transcription. Acetylation of lysine residues within proteins has emerged as an important mechanism used by cells to overcome this repression. The acetylation of non-histone proteins such as transcription factors, as well as histones appears to be involved in this process. Acetylation may result in structural transitions as well as specific signaling within discrete chromatin domains. The role of acetylation in intracellular signaling has been inferred from the binding of acetylated peptides by the conserved bromodomain. Furthermore, recent findings suggest that bromodomain/acetylated-lysine recognition can serve as a regulatory mechanism in protein-protein interactions in numerous cellular processes such as chromatin remodeling and transcriptional activation. The reversible lysine acetylation of histones and non-histone proteins plays a vital role in the regulation of many cellular processes including chromatin dynamics and transcription, gene silencing, cell cycle progression, apoptosis, differentiation, DNA replication, DNA repair, nuclear import, and neuronal repression. More than 20 acetyltransferases and 18 deacetylases have been identified so far, but the mechanistic details of substrate selection and site specificity of these enzymes remain unclear. Over 40 transcription factors and 30 other nuclear, cytoplasmic, bacterial, and viral proteins have been shown to be acetylated in vivo.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Acetyl Lysine
• Description
  N terminal acetylation or CH3CO as epigenetic regulation of Anti-Acetyl Lysine by NATs.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Lysine  
• Gene symbol
  PLOD2, KMT5A, KDM6B
• Short name
  Anti-Acetyl Lysine
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Acetyl Lysine Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:9082
• Gene
  PLOD2
• Long gene name
  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
• Synonyms gene name
  • procollagen-lysine, 2-oxoglutarate 5-dioxygenase (lysine hydroxylase) 2
  • procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
• Synonyms
  • LH2
• Synonyms name
  • lysyl hydroxlase 2
  • procollagen-lysine 5-dioxygenase
• GenBank acession
  • U84573
• Locus
  3q24
• Discovery year
  1996-12-18
• Entrez gene record
  5352
• Pubmed identfication
  • 9054364
• RefSeq identity
  • NM_000935
• Classification
  • Procollagen-lysine,2-oxoglutarate 5-dioxygenase family
• VEGA ID
  OTTHUMG00000159417
• Locus Specific Databases
  • PLOD2 variant database

Gene info

• Identity
  HGNC:29489
• Gene
  KMT5A
• Long gene name
  lysine methyltransferase 5A
• Synonyms gene
  • SETD8
• Synonyms gene name
  • SET domain containing (lysine methyltransferase) 8
  • lysine (K)-specific methyltransferase 5A
• Synonyms
  • SET8
  • SET07
  • PR-Set7
• GenBank acession
  • AY102937
• Locus
  12q24.31
• Discovery year
  2006-02-15
• Entrez gene record
  387893
• Pubmed identfication
  • 15933070
  • 12086618
  • 12121615
• RefSeq identity
  • NM_020382
• Classification
  • SET domain containing
  • Lysine methyltransferases
• VEGA ID
  OTTHUMG00000150477

Gene info

• Identity
  HGNC:29012
• Gene
  KDM6B
• Long gene name
  lysine demethylase 6B
• Synonyms gene
  • JMJD3
• Synonyms gene name
  • jumonji domain containing 3
  • jumonji domain containing 3, histone lysine demethylase
  • lysine (K)-specific demethylase 6B
• Synonyms
  • KIAA0346
• GenBank acession
  • AB002344
• Locus
  17p13.1
• Discovery year
  2004-02-27
• Entrez gene record
  23135
• Pubmed identfication
  • 10662545
  • 9205841
• RefSeq identity
  • NM_001080424
• Classification
  • Lysine demethylases
• VEGA ID
  OTTHUMG00000178021

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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