Ac-DEVD-AFC

• Catalog number
  A190273
• Price
  Please ask
• Size
  1 mg

• Chemical available in other sizes
  Please inquire size and price
• Stock availability
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• Cas number
  201608-14-2
• Chemical s molecular weight
  729.61
• Chemical s main applications
  Ac-DEVD-AFC is a fluorogenic substrate for caspase-3 (CPP32) and related cysteine proteases, which emits a blue to green shift in fluorescence. It also acts as a substrate for granzyme B-processed caspase-6, caspase-7, caspase-8, and caspase-10. It is known that Ac-DEVD-AFC has a greater Stokes' shift than Ac-DEVD-AMC once it has been cleaved. Since caspase-3 is an effector caspase, it is involved in the cleavage of many substrates which promote apoptosis. This indicator excites light at 400 nm and emits light at 505 nm. In addition, Ac-DEVD-AFC is modeled after Asp216 on caspase-3, the PARP cleavage site. Ac-DEVD-AFC is an essential indicator used to monitor the cellular effects of caspase-3.
• Other name
  N-Acetyl-L-α-aspartyl-L-α-glutamyl-L-valyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-α-asparagine;
• Chemical s formula
  C30H34F3N5O13
• Physical properties
  No Data Available
• Melting temperature
  No Data Available
• Boiling temperature
  No Data Available
• Chemical s soluble in
  No Data Available
• Stability conditions
  No Data Available
• Storage
  No Data Available
• Chemical s specifications

• Gene target
  Ac-DEVD-AFC  
• Short name
  Ac-DEVD-AFC
• Alternative name
  Ac-DEVD-AFC

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