ABT-869

• Catalog number
  1615-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  Linifanib
• Description
  ABT-869 is multi-targeted inhibitor of all members of the VEGF and PDGF receptor families (e.g., KDR, IC₅₀ value of 4 nM), but has much less activity (IC₅₀ values >1 µM) against unrelated receptor tyrosine kinases, soluble tyrosine kinases or serine/threonine kinases. The kinase inhibition profile of ABT-869 is evident in cellular assays of RTK phosphorylation (IC₅₀ values of 2, 4 and 7 nM for PDGFRβ, KDR and CSF-1R, respectively) and VEGF-stimulated proliferation (0.2 nM IC₅₀ for human endothelial cells).
• CAS Number
  796967-16-3
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₁H₁₈FN₅O
• Molecular Weight
  375.41
• Cell Permeable
  Yes
• Purity
  ≥99%
• Solubilities
  DMSO
• Handling
  Protect from air and moisture
• Tag Line
  A VEGFR and PDGFR kinase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  RT
• Shelf Life
  24months
• MDL Number
  MFCD11840918
• PubChem CID
  11485656
• PubChem CID Link
• SMILES
  CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=CC=C3)NN=C4N
• InChi
  InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25, 28)
• InChi Key
  MPVGZUGXCQEXTM-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  ABT-869  
• Short name
  ABT-869
• Alternative name
  ABT-869

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