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Stock availabilitIn Stock
In Stock
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CAS number
667463-62-9
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Description
PDK1 kinase inhibitor
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Molecular weight
356,2 g/mol
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Primary research fields
Cell Signaling
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Other name
(2’Z,3’E)-6-Bromoindirubin-3′-oxime, 6-BIO, 6BIO, (3Z)-6-Bromo-3-[(3E)-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C16H10BrN3O2
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Origin
Synthetic
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Purity pourcentage
≥98% (HPLC)
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Soluble in
Soluble to 10 mM in DMSO and to 10 mM in ethanol
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Physical appearance
Dark red solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Skin irritation (Category 2), H315 Eye irritation (Category 2A), H319 Specific target organ toxicity-single exposure ( Category 3 ), Respiratory system, H335 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ eye protection/ face protection. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P321 Specific treatment (see supplemental first aid instru ctions on this label). P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant.
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PubChem number
11405589
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Scientific context
6BIO is an inhibitor of phosphoinositide-dependent kinase 1 (PDK1), and a potent, reversible and ATP-competitive inhibitor of glycogen synthase kinase-3α/β (GSK-3α/β). It maintains self-renewal and pluripotency in embryonic stem cells via activation of the Wnt signaling pathway.
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Bibliography
1. Valerio A., et al. (2011) J. Neurochem. 116(6): 1148–1159. 2. Yasuhara R., et al. (2010) J. Biol. Chem. 285(1): 317–327. 3. Meijer L., et al. (2003) Chem. & Bio. 10(12): 1255–1266.
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Release date
1-Oct-2014
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of 6BIO (SIH-422), a ESC self-renewal. CAS #: 667463-62-9. Molecular Formula: C16H10BrN3O2. Molecular Weight: 356.2 g/mol. Chemical structure of 6BIO, a ESC self-renewal (SIH-422). CAS # 667463-62-9. Molecular Formula: C16H10BrN3O2.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.025
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
