5-Lipoxygenase Inhibitor Screening Kit (Fluorometric)

• Catalog number
  K980-100
• Price
  Please ask
• Size
  100 assays

• Description
  Highly Sensitive; Includes recombinant Zileuton as inhibitor control
• Summary
  • Detection method- Fluorescence (Ex/Em 500/536 nm) • Species reactivity- Human • Applications -Screening of potential inhibitors of 5-lipoxygenase
• Detection Method
  Fluorescence (Ex/Em 500/536 nm)
• Species Reactivity
  Human
• Applications
  Screening of potential inhibitors of 5-lipoxygenase
• Features Benefits
  • Simple procedure; takes only ~40 min • Fast and convenient
• Storage Conditions
  -20°C
• Shipping Conditions
  gel pack
• Shelf life
  12 months
• Background
  5-Lipoxygenase (5-LOX) is a non-heme iron-containing dioxygenase that converts unsaturated fatty acids to epoxides; for example the synthesis of leukotrienes from arachidonic acid. It is involved in processes like cell proliferation, differentiation and inflammation and has been implicated in inflammation and hyper proliferation mediated diseases like asthma, rheumatoid arthritis and cancer. Research for identifying potential remedies for such diseases involves the identification of inhibitors of 5-lipoxygenase. BioVision’s 5-Lipoxygenase Inhibitor Screening Kit uses Zileuton, a well-known 5-lipoxygenase inhibitor as positive control, and provides a simple and fast method to screen/ characterize potential 5-lipoxygenase inhibitors
• Data Sheet Link
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  5-Lipoxygenase   Inhibitor   Screening   Kit   Fluorometric  
• Short name
  5-Lipoxygenase Inhibitor Screening Kit (Fluorometric)
• Alternative name
  5-Lipoxygenase suppressor detection reagent (fluorescence)
• Alternative technique
  kits
• Alternative to gene target
  v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, C-Kit and CD117 and PBT and SCFR, KIT and IDBG-18980 and ENSG00000157404 and 3815, transferase activity, Extracellular, Kit and IDBG-172083 and ENSMUSG00000005672 and 16590, KIT and IDBG-642326 and ENSBTAG00000002699 and 280832

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