15 Lipoxygenase 1 Antibody, ALEXA FLUOR 555

  • Catalog number
    bs-6505R-A555
  • Price
    Please ask
  • Size
    100ul
  • Long name
    15 Lipoxygenase 1 Polyclonal Antibody, ALEXA FLUOR 555 Conjugated
  • Also known as
    Anti-15 Lipoxygenase 1 PAb ALEXA FLUOR 555
  • Category
    Conjugated Primary Antibodies
  • Conjugated with
    ALEXA FLUOR® 555
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Target Antigen
    15 Lipoxygenase 1
  • Specificity
    This is a highly specific antibody against 15 Lipoxygenase 1.
  • Modification
    Unmodified
  • Modification Site
    None
  • Clonality
    Polyclonal
  • Clone
    Polyclonal antibody
  • Concentration
    1ug per 1ul
  • Immunogen range
    610-662/662
  • Subcellular location
    Cytoplasm
  • Source
    This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ALOX15/15 Lipoxygenase 1
  • Gene ID Number
    246
  • Swiss Prot
    P16050
  • Tested applications
    IF(IHC-P)
  • Recommended dilutions
    IF(IHC-P)(1:50-200)
  • Crossreactivity
    Human, Mouse, Rat
  • Cross reactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Background of the antigen
    Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.
  • Purification
    Purified by Protein A.
  • Storage conditions
    Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
  • Excitation emission
    553nm/568nm
  • Synonyms
    12-LOX; 15LOX-1; 15-LOX-1; Arachidonate 15-lipoxygenase; 15-LOX; 12/15-lipoxygenase; Arachidonate 12-lipoxygenase, leukocyte-type; Arachidonate omega-6 lipoxygenase; ALOX15; LOG15
  • Properties
    For facs or microscopy Alexa 1 conjugate. Very high photo stable ALEXA conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • Conjugation
    Alexa Fluor, ALEXA FLUOR 555
  • French translation
    anticorps
  • Gene target
  • Gene symbol
    ALOX15P1, ALOX15
  • Short name
    Anti-15 Lipoxygenase 1
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Isotype
    Immunoglobulin G (IgG)
  • Label
    ALEXA FLUOR 555
  • Alternative name
    15 Lipoxygenase 1 Polyclonal Antibody, ALEXA FLUOR 555
  • Alternative technique
    antibodies
Gene info
  • Identity
  • Gene
  • Long gene name
    arachidonate 15-lipoxygenase pseudogene 1
  • Synonyms gene
  • Synonyms gene name
    • arachidonate 15-lipoxygenase pseudogene
  • Locus
  • Discovery year
    2000-11-29
  • Entrez gene record
  • RefSeq identity
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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