Atractyloside Calcium Salt
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Catalog number
A794540
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Price
Please ask
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Size
500 µg
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Chemical available in other sizes
Please inquire size and price
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Stock availability
In Stock
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Cas number
This product doesn't have CAS Number
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Chemical s molecular weight
783.9
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Chemical s main applications
Atractyloside Calcium Salt is a specific inhibitor of the adenine nucleotide translocase (ANT), which is a mitochondrial ADP/ATP carrier. It is also a proapoptotic ligand of ANT that induces pore formation by ANT, and results in permeabilization of the mitochondria membrane. Studies on rat hearts suggest that Atractyloside inhibits chloride channels from the mitochondrial membrane. It is used to probe the source of procaspase 8 in human fibroblasts and mouse clonal striatal cells, as related to death receptor-mediated apoptosis. Atractyloside induces the release of ahyaluronidase-induced murine WW domain-containing oxidoreductase from cultured COS-7 cells, with respect to tumor necrosis factor cytotoxicity.
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Chemical s category
Apoptosis, Heterocycles, Inhibitors, Chelating Agents & Ligands, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium
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Other name
(2β,15α)-15-Hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-β-D-glucopyranosyl]oxy]-19-Norkaur-16-en-18-oic Acid Calcium Salt; 19-Norkaur-16-en-18-oic acid deriv. 1H-2,10a-Ethanophenanthrene Calcium Salt
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Chemical s formula
C30H43Ca1.5O16S2
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Physical properties
Pale Yellow Solid
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Melting temperature
226-229°C (dec.)
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Boiling temperature
No Data Available
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Chemical s soluble in
DMSO, Methanol
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Stability conditions
No Data Available
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Storage
Hygroscopic, -20°C Freezer, Under inert atmosphere
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