(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (ent-Ruxolitinib)

• Catalog number
  C988940
• Price
  Please ask
• Size
  5 mg

• Chemical available in other sizes
  Please inquire size and price
• Stock availability
  Available in 2-3 weeks
• Cas number
  941685-37-6
• Chemical s molecular weight
  306.37
• Chemical s main applications
  (3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile is a newly developed JAK2 inhibitor therapy aimed to improve MPN-associated splenomegaly and systemic symptoms. The opposite enantiomer of Ruxolitinib (R702000).
• Chemical s category
  Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
• Other name
  (βS)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile
• Chemical s formula
  C17H18N6
• Physical properties
  No Data Available
• Melting temperature
  No Data Available
• Boiling temperature
  No Data Available
• Chemical s soluble in
  No Data Available
• Stability conditions
  No Data Available
• Storage
  No Data Available
• Chemical s specifications

• Gene target
  3-Cyclopentyl-3   7H-pyrrolo[2   3-d]pyrimidin-4-yl   1H-pyrazol-1-yl]propanenitrile   ent-Ruxolitinib  
• Gene symbol
  VSIR, IGHV7-4-1, TRV-CAC1-4, TRQ-CTG1-4, TRL-CAG1-4, TRG-GCC1-4, TRH-GTG1-4, TRE-CTC1-4, TRUND-NNN4-1, TRW-CCA4-1
• Short name
  (3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2 3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (ent-Ruxolitinib)
• Alternative name
  (3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (ent-Ruxolitinib)

Gene info

• Identity
  HGNC:30085
• Gene
  VSIR
• Long gene name
  V-set immunoregulatory receptor
• Synonyms gene
  • C10orf54
• Synonyms gene name
  • chromosome 10 open reading frame 54
• Synonyms
  • SISP1
  • GI24
  • B7-H5
  • B7H5
  • VISTA
  • PD-1H
  • Dies1
• Synonyms name
  • stress induced secreted protein 1
  • V-domain Ig suppressor of T cell activation
  • PDCD1 homolog
• GenBank acession
  • AF193048
• Locus
  10q22.1
• Discovery year
  2005-10-06
• Entrez gene record
  64115
• Pubmed identfication
  • 12975309
  • 24691993
  • 25279955
• RefSeq identity
  • NM_022153
• Classification
  • B7 family
  • V-set domain containing
• VEGA ID
  OTTHUMG00000018426

Gene info

• Identity
  HGNC:5665
• Gene
  IGHV7-4-1
• Long gene name
  immunoglobulin heavy variable 7-4-1
• GenBank acession
  • L10057
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  57289
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000191141

Gene info

• Identity
  HGNC:34541
• Gene
  TRV-CAC1-4
• Long gene name
  tRNA-Val (anticodon CAC) 1-4
• Synonyms gene
  • TRNAV4
• Synonyms gene name
  • transfer RNA valine 4 (anticodon CAC)
  • transfer RNA-Val (CAC) 1-4
• Synonyms
  • tRNA-Val-CAC-1-4
• GenBank acession
  • HG984114
• Locus
  5q35.3
• Discovery year
  2008-08-27
• Entrez gene record
  100189541
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34884
• Gene
  TRQ-CTG1-4
• Long gene name
  tRNA-Gln (anticodon CTG) 1-4
• Synonyms gene
  • TRNAQ24
  • TRQ-CTG1-1
• Synonyms gene name
  • transfer RNA glutamine 24 (anticodon CUG)
  • transfer RNA-Gln (CTG) 1-1
  • transfer RNA-Gln (CTG) 1-4
• Synonyms
  • tRNA-Gln-CTG-1-4
• GenBank acession
  • HG983716
• Locus
  15q22.31
• Discovery year
  2008-08-29
• Entrez gene record
  100189317
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34932
• Gene
  TRL-CAG1-4
• Long gene name
  tRNA-Leu (anticodon CAG) 1-4
• Synonyms gene
  • TRNAL35
• Synonyms gene name
  • transfer RNA leucine 35 (anticodon CAG)
  • transfer RNA-Leu (CAG) 1-4
• Synonyms
  • tRNA-Leu-CAG-1-4
• GenBank acession
  • HG983892
• Locus
  1q23.3
• Discovery year
  2008-08-29
• Entrez gene record
  100189364
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34722
• Gene
  TRG-GCC1-4
• Long gene name
  tRNA-Gly (anticodon GCC) 1-4
• Synonyms gene
  • TRNAG15
• Synonyms gene name
  • transfer RNA glycine 15 (anticodon GCC)
  • transfer RNA-Gly (GCC) 1-4
• Synonyms
  • tRNA-Gly-GCC-1-4
• GenBank acession
  • HG983809
• Locus
  1q23.3
• Discovery year
  2008-08-29
• Entrez gene record
  100189160
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34736
• Gene
  TRH-GTG1-4
• Long gene name
  tRNA-His (anticodon GTG) 1-4
• Synonyms gene
  • TRNAH7
• Synonyms gene name
  • transfer RNA histidine 7 (anticodon GUG)
  • transfer RNA-His (GTG) 1-4
• Synonyms
  • tRNA-His-GTG-1-4
• GenBank acession
  • HG983835
• Locus
  1q21.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189174
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34822
• Gene
  TRE-CTC1-4
• Long gene name
  tRNA-Glu (anticodon CTC) 1-4
• Synonyms gene
  • TRNAE18
• Synonyms gene name
  • transfer RNA glutamic acid 18 (anticodon CUC)
  • transfer RNA-Glu (CTC) 1-4
• Synonyms
  • tRNA-Glu-CTC-1-4
• GenBank acession
  • HG983756
• Locus
  1q23.3
• Discovery year
  2008-08-29
• Entrez gene record
  100189259
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:50816
• Gene
  TRUND-NNN4-1
• Long gene name
  tRNA-undetermined (NNN) 4-1
• Synonyms gene name
  • transfer RNA-undetermined (NNN) 4-1
• Synonyms
  • tRNA-Und-NNN-4-1
• GenBank acession
  • HG984093
• Locus
  1p36.23
• Discovery year
  2014-06-20
• Entrez gene record
  103482530
• Pubmed identfication
  • 18984615
• Classification
  • Cytoplasmic transfer RNA pseudogenes

Gene info

• Identity
  HGNC:34733
• Gene
  TRW-CCA4-1
• Long gene name
  tRNA-Trp (anticodon CCA) 4-1
• Synonyms gene
  • TRNAW5
• Synonyms gene name
  • transfer RNA tryptophan 5 (anticodon CCA)
  • transfer RNA-Trp (CCA) 4-1
• Synonyms
  • tRNA-Trp-CCA-4-1
• GenBank acession
  • HG984069
• Locus
  12q23.1
• Discovery year
  2008-08-29
• Entrez gene record
  100189171
• Classification
  • Cytoplasmic transfer RNAs

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