3-Oxo-1-phenyl-d5-3-(2’-hydroxy-5-benzyloxyphenyl)propene

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Cas number

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Chemical s molecular weight

335.41
Chemical s main applications

3-Oxo-1-phenyl-d5-3-(2’-hydroxy-5-benzyloxyphenyl)propene is the labeled analogue of 3-Oxo-1-phenyl-3-(2’-hydroxy-5-benzyloxyphenyl)propene (O870100), a potential inhibitor of HIV-1 integrase (IN) and human LEDGF/p75, which represents a novel target for anti-HIV therapy.
Chemical s category

Aromatics, Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals
Other name

(E)-1-(5-(Benzyloxy)-2-hydroxyphenyl)-3-phenyl-d5-prop-2-en-1-one; 5’-Benzyloxy-2’-hydroxychalcone; 1-(5-Benzyloxy-2-hydroxy-phenyl)-3-phenyl-d5-propenone; (2E)-1-[2-Hydroxy-4-(phenylmethoxy)phenyl]-3-phenyl-d5-2-propen-1-one; NPD 227-d5
Chemical s formula

C22H13D5O3
Physical properties

No Data Available
Melting temperature

No Data Available
Boiling temperature

No Data Available
Chemical s soluble in

No Data Available
Stability conditions

No Data Available
Storage

No Data Available
Chemical s specifications

Gene target

3-Oxo-1-phenyl-d5-3 hydroxy-5-benzyloxyphenyl propene
Gene symbol

IGHVIII-5-1, TRL-CAG1-5, TRE-CTC1-5, TRG-GCC1-5, CYB5AP3, TRUND-NNN5-1, TEAD3, TRV-CAC1-5, TRK-TTT5-1, TRA-AGC5-1
Short name

3-Oxo-1-phenyl-d5-3-(2’-hydroxy-5-benzyloxyphenyl)propene
Alternative name

3-Oxo-1-phenyl-d5-3-(2’-hydroxy-5-benzyloxyphenyl)propene

Identity

HGNC:5702
Gene

IGHVIII-5-1
Long gene name

immunoglobulin heavy variable (III)-5-1 (pseudogene)
Synonyms gene name
- immunoglobulin heavy variable (III)-5-1
- immunoglobulin heavy variable (III)-5-1 pseudogene
Synonyms
- IGHV(III)-5-1
GenBank acession
- AB019440
Locus

14q32.33
Discovery year

2000-04-17
Entrez gene record

28354
RefSeq identity
- NG_001019
Classification
- Immunoglobulin heavy locus at 14q32.33
VEGA ID

OTTHUMG00000152274

Identity

HGNC:34701
Gene

TRL-CAG1-5
Long gene name

tRNA-Leu (anticodon CAG) 1-5
Synonyms gene
- TRNAL14
Synonyms gene name
- transfer RNA leucine 14 (anticodon CAG)
- transfer RNA-Leu (CAG) 1-5
Synonyms
- tRNA-Leu-CAG-1-5
GenBank acession
- HG983893
Locus

1q23.3
Discovery year

2008-08-29
Entrez gene record

100189139
Classification
- Cytoplasmic transfer RNAs

Identity

HGNC:34576
Gene

TRE-CTC1-5
Long gene name

tRNA-Glu (anticodon CTC) 1-5
Synonyms gene
- TRNAE5
Synonyms gene name
- transfer RNA glutamic acid 5 (anticodon CUC)
- transfer RNA-Glu (CTC) 1-5
Synonyms
- tRNA-Glu-CTC-1-5
GenBank acession
- HG983757
Locus

1q23.3
Discovery year

2008-08-29
Entrez gene record

100189017
Classification
- Cytoplasmic transfer RNAs

Identity

HGNC:34850
Gene

TRG-GCC1-5
Long gene name

tRNA-Gly (anticodon GCC) 1-5
Synonyms gene
- TRNAG27
Synonyms gene name
- transfer RNA glycine 27 (anticodon GCC)
- transfer RNA-Gly (GCC) 1-5
Synonyms
- tRNA-Gly-GCC-1-5
GenBank acession
- HG983810
Locus

21q21.1
Discovery year

2008-08-29
Entrez gene record

100189284
Classification
- Cytoplasmic transfer RNAs

Identity

HGNC:2574
Gene

CYB5AP3
Long gene name

cytochrome b5 type A pseudogene 3
Synonyms gene
- CYB5P3
Synonyms gene name
- cytochrome b-5 pseudogene 3
- cytochrome b5 type A (microsomal) pseudogene 3
Synonyms
- Psgb-5-1
GenBank acession
- M25765
Locus

14q32.12
Discovery year

1994-07-29
Entrez gene record

1531
Pubmed identfication
- 8262522
- 2775258
RefSeq identity
- NG_002437

Identity

HGNC:33245
Gene

TRV-CAC1-5
Long gene name

tRNA-Val (anticodon CAC) 1-5
Synonyms gene
- TRV6
- TRNAV6
Synonyms gene name
- transfer RNA valine 6 (anticodon CAC)
- transfer RNA-Val (CAC) 1-5
Synonyms
- tRNA-Val-CAC-1-5
GenBank acession
- HG984115
Locus

5q35.3
Discovery year

2007-01-11
Entrez gene record

100049614
Pubmed identfication
- 2766931
Classification
- Cytoplasmic transfer RNAs

Identity

HGNC:34801
Gene

TRK-TTT5-1
Long gene name

tRNA-Lys (anticodon TTT) 5-1
Synonyms gene
- TRNAK23
Synonyms gene name
- transfer RNA lysine 23 (anticodon UUU)
- transfer RNA-Lys (TTT) 5-1
Synonyms
- tRNA-Lys-TTT-5-1
GenBank acession
- HG983937
Locus

11q12.1
Discovery year

2008-08-29
Entrez gene record

100189238
Classification
- Cytoplasmic transfer RNAs

Identity

HGNC:34606
Gene

TRA-AGC5-1
Long gene name

tRNA-Ala (anticodon AGC) 5-1
Synonyms gene
- TRNAA8
Synonyms gene name
- transfer RNA alanine 8 (anticodon AGC)
- transfer RNA-Ala (AGC) 5-1
Synonyms
- tRNA-Ala-AGC-5-1
GenBank acession
- HG983553
Locus

6p22.1
Discovery year

2008-08-29
Entrez gene record

100189047
Classification
- Cytoplasmic transfer RNAs

Name

Cloning, Molecular
Concept

Scope note: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Tree numbers
- E05.393.220
Qualifiers

drug effects, methods, radiation effects