3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

• Catalog number
  A602050
• Price
  Please ask
• Size
  1 mg

• Chemical available in other sizes
  Please inquire size and price
• Stock availability
  In Stock
• Cas number
  1224844-38-5
• Chemical s molecular weight
  309.33
• Chemical s main applications
  3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine is a potent and selective TORC1/2 inhibitor with broad oral antitumor activity. TORC1/2 inhibitors are mechanistically distinct from rapamycinand offer a compelling approach to the treatment of cancer by targeting translational control, cell metabolism, growth andangiogenesis.
• Chemical s category
  Amines, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
• Other name
  INK 128; MLN 0128; Sapanisertib
• Chemical s formula
  C15H15N7O
• Physical properties
  White Solid
• Melting temperature
  270-272°C (dec.)
• Boiling temperature
  No Data Available
• Chemical s soluble in
  DMSO (Slightly), Methanol (Slightly)
• Stability conditions
  No Data Available
• Storage
  Hygroscopic, Refrigerator, under inert atmosphere
• Chemical s specifications

• Gene target
  2-Amino-5-benzoxazolyl   1-methylethyl   1H-pyrazolo[3   4-d]pyrimidin-4-amine  
• Gene symbol
  VSIR, TSPAN5, NTF4, HCG4P5, OR2J1, TRP-TGG3-5, TRS-AGA2-4, TRX-CAT1-4, TRK-CTT2-4, TRK-TTT3-5
• Short name
  3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3 4-d]pyrimidin-4-amine
• Alternative name
  3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Gene info

• Identity
  HGNC:30085
• Gene
  VSIR
• Long gene name
  V-set immunoregulatory receptor
• Synonyms gene
  • C10orf54
• Synonyms gene name
  • chromosome 10 open reading frame 54
• Synonyms
  • SISP1
  • GI24
  • B7-H5
  • B7H5
  • VISTA
  • PD-1H
  • Dies1
• Synonyms name
  • stress induced secreted protein 1
  • V-domain Ig suppressor of T cell activation
  • PDCD1 homolog
• GenBank acession
  • AF193048
• Locus
  10q22.1
• Discovery year
  2005-10-06
• Entrez gene record
  64115
• Pubmed identfication
  • 12975309
  • 24691993
  • 25279955
• RefSeq identity
  • NM_022153
• Classification
  • B7 family
  • V-set domain containing
• VEGA ID
  OTTHUMG00000018426

Gene info

• Identity
  HGNC:17753
• Gene
  TSPAN5
• Long gene name
  tetraspanin 5
• Synonyms gene
  • TM4SF9
• Synonyms gene name
  • transmembrane 4 superfamily member 9
• Synonyms
  • Tspan-5
  • NET-4
• Locus
  4q23
• Discovery year
  2003-07-21
• Entrez gene record
  10098
• RefSeq identity
  • NM_005723
• Classification
  • Tetraspanins
• VEGA ID
  OTTHUMG00000131008

Gene info

• Identity
  HGNC:8024
• Gene
  NTF4
• Long gene name
  neurotrophin 4
• Synonyms gene
  • NTF5
• Synonyms gene name
  • neurotrophin 5 (neurotrophin 4/5)
• Synonyms
  • NT-4/5
  • GLC1O
• Synonyms name
  • neurotrophic factor 4
• Locus
  19q13.33
• Discovery year
  1992-10-15
• Entrez gene record
  4909
• Pubmed identfication
  • 1496419
• RefSeq identity
  • NM_006179
• Classification
  • Neurotrophins
• VEGA ID
  OTTHUMG00000191728

Gene info

• Identity
  HGNC:22925
• Gene
  HCG4P5
• Long gene name
  HLA complex group 4 pseudogene 5
• Synonyms
  • HCGIV-05
  • HCGIV.4
  • HCGIV-5
• Synonyms name
  • HCGIV-05 pseudogene
• Locus
  6p21.3
• Discovery year
  2003-09-01
• Entrez gene record
  353003
• Pubmed identfication
  • 10557312
• RefSeq identity
  • NG_016115
• VEGA ID
  OTTHUMG00000031152

Gene info

• Identity
  HGNC:8259
• Gene
  OR2J1
• Long gene name
  olfactory receptor family 2 subfamily J member 1
• Synonyms gene
  • OR2J1P
• Synonyms gene name
  • olfactory receptor, family 2, subfamily J, member 1 pseudogene
  • olfactory receptor, family 2, subfamily J, member 1
  • olfactory receptor, family 2, subfamily J, member 1 (gene/pseudogene)
  • olfactory receptor family 2 subfamily J member 1 (gene/pseudogene)
• Synonyms
  • OR6-5
  • hs6M1-4
  • dJ80I19.2
• Locus
  6p22.1
• Discovery year
  1999-12-09
• Entrez gene record
  442185
• RefSeq identity
  • NM_001348294
• Classification
  • Olfactory receptors, family 2
• VEGA ID
  OTTHUMG00000031280

Gene info

• Identity
  HGNC:34847
• Gene
  TRP-TGG3-5
• Long gene name
  tRNA-Pro (anticodon TGG) 3-5
• Synonyms gene
  • TRNAP16
  • TRP-TGG3-4
• Synonyms gene name
  • transfer RNA proline 16 (anticodon UGG)
  • transfer RNA-Pro (TGG) 3-4
  • transfer RNA-Pro (TGG) 3-5
• Synonyms
  • tRNA-Pro-TGG-3-5
• GenBank acession
  • HG984000
• Locus
  16p13.3
• Discovery year
  2008-08-29
• Entrez gene record
  100189281
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34810
• Gene
  TRS-AGA2-4
• Long gene name
  tRNA-Ser (anticodon AGA) 2-4
• Synonyms gene
  • TRNAS19
  • TRS-AGA2-5
• Synonyms gene name
  • transfer RNA serine 19 (anticodon AGA)
  • transfer RNA-Ser (AGA) 2-5
  • transfer RNA-Ser (AGA) 2-4
• Synonyms
  • tRNA-Ser-AGA-2-4
• GenBank acession
  • HG984013
• Locus
  6p22.1
• Discovery year
  2008-08-29
• Entrez gene record
  100189247
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34599
• Gene
  TRX-CAT1-4
• Long gene name
  tRNA-iMet (anticodon CAT) 1-4
• Synonyms gene
  • TRNAM4
  • TRX-CAT1-5
• Synonyms gene name
  • transfer RNA methionine 4 (anticodon CAU)
  • transfer RNA-iMet (CAT) 1-5
  • transfer RNA-iMet (CAT) 1-4
• Synonyms
  • tRNA-iMet-CAT-1-4
• Synonyms name
  • transfer RNA initiator methionine (CAT) 1-5
• GenBank acession
  • HG984140
• Locus
  6p22.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189040
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34671
• Gene
  TRK-CTT2-4
• Long gene name
  tRNA-Lys (anticodon CTT) 2-4
• Synonyms gene
  • TRNAK14
  • TRK-CTT2-5
• Synonyms gene name
  • transfer RNA lysine 14 (anticodon CUU)
  • transfer RNA-Lys (CTT) 2-5
  • transfer RNA-Lys (CTT) 2-4
• Synonyms
  • tRNA-Lys-CTT-2-4
• GenBank acession
  • HG983914
• Locus
  6p22.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189110
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:12314
• Gene
  TRK-TTT3-5
• Long gene name
  tRNA-Lys (anticodon TTT) 3-5
• Synonyms gene
  • TRK1
  • TRNAK1
  • TRK-TTT3-4
• Synonyms gene name
  • tRNA lysine 1
  • tRNA lysine 1 (anticodon UUU)
  • transfer RNA lysine 1 (anticodon UUU)
  • transfer RNA-Lys (TTT) 3-4
  • transfer RNA-Lys (TTT) 3-5
• Synonyms
  • tRNA-Lys-TTT-3-5
• GenBank acession
  • HG983934
• Locus
  17p13.1
• Discovery year
  1989-06-30
• Entrez gene record
  7206
• Pubmed identfication
  • 6296772
• Classification
  • Cytoplasmic transfer RNAs

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