(S)-Isopropyl 2-(((R)-(((2R,3R,4R,5R)-3-((tert-Butyldimethylsilyl)oxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate

• Catalog number
  I872830
• Price
  Please ask
• Size
  2,5 mg

• Chemical available in other sizes
  Please inquire size and price
• Stock availability
  Pending QC
• Cas number
  This product doesn't have CAS Number
• Chemical s molecular weight
  643.71
• Chemical s main applications
  (S)-Isopropyl 2-(((R)-(((2R,3R,4R,5R)-3-((tert-Butyldimethylsilyl)oxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
• Chemical s formula
  C28H43FN3O9PSi
• Physical properties
  White Solid
• Melting temperature
  No Data Available
• Boiling temperature
  No Data Available
• Chemical s soluble in
  Chloroform, Dichloromethane, Methanol
• Stability conditions
  No Data Available
• Storage
  No Data Available
• Chemical s specifications

• Gene target
  Isopropyl   tert-Butyldimethylsilyl   oxy   4-dioxo-3   4-dihydropyrimidin-1   4-fluoro-4-methyltetrahydrofuran-2-yl   methoxy   phenoxy   phosphoryl   amino   propanoate  
• Gene symbol
  TRL-AAG2-4, MIR3130-2, TRP-AGG2-4, TRG-TCC2-4, TRD-GTC2-4, TRG-GCC2-4, TRR-ACG2-4, TRN-GTT2-4, CHST9, TRM-CAT4-2
• Short name
  (S)-Isopropyl 2-(((R)-(((2R 3R 4R 5R)-3-((tert-Butyldimethylsilyl)oxy)-5-(2 4-dioxo-3 4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
• Alternative name
  (S)-Isopropyl 2-(((R)-(((2R,3R,4R,5R)-3-((telomerase reverse transcriptase-Butyldimethylsilyl)oxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
• Alternative to gene target
  telomerase reverse transcriptase, CMM9 and DKCA2 and DKCB4 and EST2 and hEST2 and hTRT and PFBMFT1 and TCS1 and TP2 and TRT, TERT and IDBG-10998 and ENSG00000164362 and 7015, telomeric RNA binding, nuclei, Tert and IDBG-165912 and ENSMUSG00000021611 and 21752, BT.60929 and IDBG-632169 and ENSBTAG00000012567 and 518884

Gene info

• Identity
  HGNC:34857
• Gene
  TRL-AAG2-4
• Long gene name
  tRNA-Leu (anticodon AAG) 2-4
• Synonyms gene
  • TRNAL27
  • TRL-AAG2-2
• Synonyms gene name
  • transfer RNA leucine 27 (anticodon AAG)
  • transfer RNA-Leu (AAG) 2-2
  • transfer RNA-Leu (AAG) 2-4
• Synonyms
  • tRNA-Leu-AAG-2-4
• GenBank acession
  • HG983872
• Locus
  16p12.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189291
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:38363
• Gene
  MIR3130-2
• Long gene name
  microRNA 3130-2
• Synonyms gene
  • MIR3130-4
• Synonyms gene name
  • microRNA 3130-4
• Synonyms
  • hsa-mir-3130-2
  • hsa-mir-3130-4
• Locus
  2q33.3
• Discovery year
  2010-04-30
• Entrez gene record
  100423002
• RefSeq identity
  • NR_036078
• Classification
  • MicroRNAs

Gene info

• Identity
  HGNC:34631
• Gene
  TRP-AGG2-4
• Long gene name
  tRNA-Pro (anticodon AGG) 2-4
• Synonyms gene
  • TRNAP6
  • TRP-AGG2-2
• Synonyms gene name
  • transfer RNA proline 6 (anticodon AGG)
  • transfer RNA-Pro (AGG) 2-2
  • transfer RNA-Pro (AGG) 2-4
• Synonyms
  • tRNA-Pro-AGG-2-4
• GenBank acession
  • HG983979
• Locus
  11q13.5
• Discovery year
  2008-08-29
• Entrez gene record
  100189072
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34751
• Gene
  TRG-TCC2-4
• Long gene name
  tRNA-Gly (anticodon TCC) 2-4
• Synonyms gene
  • TRNAG17
• Synonyms gene name
  • transfer RNA glycine 17 (anticodon UCC)
  • transfer RNA-Gly (TCC) 2-4
• Synonyms
  • tRNA-Gly-TCC-2-4
• GenBank acession
  • HG983825
• Locus
  1q23.3
• Discovery year
  2008-08-29
• Entrez gene record
  100189188
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34696
• Gene
  TRD-GTC2-4
• Long gene name
  tRNA-Asp (anticodon GTC) 2-4
• Synonyms gene
  • TRNAD6
• Synonyms gene name
  • transfer RNA aspartic acid 6 (anticodon GUC)
  • transfer RNA-Asp (GTC) 2-4
• Synonyms
  • tRNA-Asp-GTC-2-4
• GenBank acession
  • HG983668
• Locus
  1q23.3
• Discovery year
  2008-08-29
• Entrez gene record
  100189134
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34533
• Gene
  TRG-GCC2-4
• Long gene name
  tRNA-Gly (anticodon GCC) 2-4
• Synonyms gene
  • TRNAG6
  • TRG-GCC2-2
• Synonyms gene name
  • transfer RNA glycine 6 (anticodon GCC)
  • transfer RNA-Gly (GCC) 2-2
  • transfer RNA-Gly (GCC) 2-4
• Synonyms
  • tRNA-Gly-GCC-2-4
• GenBank acession
  • HG983812
• Locus
  16q22.1
• Discovery year
  2008-08-20
• Entrez gene record
  100188985
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34997
• Gene
  TRR-ACG2-4
• Long gene name
  tRNA-Arg (anticodon ACG) 2-4
• Synonyms gene
  • TRNAR29
• Synonyms gene name
  • transfer RNA arginine 29 (anticodon ACG)
  • transfer RNA-Arg (ACG) 2-4
• Synonyms
  • tRNA-Arg-ACG-2-4
• GenBank acession
  • HG983600
• Locus
  6p22.1
• Discovery year
  2008-08-29
• Entrez gene record
  100189428
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34595
• Gene
  TRN-GTT2-4
• Long gene name
  tRNA-Asn (anticodon GTT) 2-4
• Synonyms gene
  • TRNAN7
• Synonyms gene name
  • transfer RNA asparagine 7 (anticodon GUU)
  • transfer RNA-Asn (GTT) 2-4
• Synonyms
  • tRNA-Asn-GTT-2-4
• GenBank acession
  • HG983633
• Locus
  13q12.3
• Discovery year
  2008-08-29
• Entrez gene record
  100189036
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:19898
• Gene
  CHST9
• Long gene name
  carbohydrate sulfotransferase 9
• Synonyms gene name
  • carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
• Synonyms
  • GALNAC4ST-2
  • GALNAC-4-ST2
• GenBank acession
  • AF239821
• Locus
  18q11.2
• Discovery year
  2002-11-29
• Entrez gene record
  83539
• Pubmed identfication
  • 11139592
  • 11445554
• RefSeq identity
  • NM_031422
• Classification
  • Sulfotransferases, membrane bound
• VEGA ID
  OTTHUMG00000179469

Gene info

• Identity
  HGNC:34922
• Gene
  TRM-CAT4-2
• Long gene name
  tRNA-Met (anticodon CAT) 4-2
• Synonyms gene
  • TRNAM19
• Synonyms gene name
  • transfer RNA methionine 19 (anticodon CAU)
  • transfer RNA-Met (CAT) 4-2
• Synonyms
  • tRNA-Met-CAT-4-2
• GenBank acession
  • HG983955
• Locus
  6p22.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189354
• Classification
  • Cytoplasmic transfer RNAs

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