14 3 3 sigma Antibody ALEXA FLUOR

14 3 3 sigma Antibody ALEXA FLUOR is available 0 time from Bioss primary conjugated antibodies. alexa fluor labs

  • Modification
    Unmodified
  • Clonality
    Polyclonal
  • Category
    Conjugated Primary Antibodies
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Source
    This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human 14-3-3 sigma
  • Specificity
    This is a highly specific antibody against 14-3-3 sigma.
  • Tested applications
    IF(IHC-P)
  • Clone
    Polyclonal antibody
  • Modification Site
    None
  • Synonyms
    14 3 3 protein sigma; 14-3-3 protein sigma; 1433S_HUMAN; Epithelial cell marker protein 1; Er; HME 1; HME1; MGC143283; Mkrn3; Mme1; OTTHUMP00000004242; RP23 137L22.11; SFN; SFN protein; Stratin; YWHAS.
  • Purification
    Purified by Protein A.
  • Crossreactivity
    Human, Mouse, Rat
  • Gene ID Number
    2810
  • Recommended dilutions
    IF(IHC-P)(1:50-200)
  • Background of the antigen
    14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms, denoted 14-3-3 b, g, e, z, h, q and s, comprise this family of signaling intermediates. 14-3-3 s, also known as SFN, stratifin, HME1 or YWHAS, is a secreted adaptor protein that is involved in regulating both general and specific signaling pathways. Expressed predominately in stratified squamous keratinising epithelium, 14-3-3 s is able to bind and modify the activity of a large number of proteins, such as KRT17 (Keratin 17), through recognition of a phosphothreonine or phosphoserine motif. When bound to Keratin 17, for example, 14-3-3 s acts to stimulate the Akt/mTOR signaling pathway by upregulating protein synthesis and cell growth. 14-3-3 s also functions to positively mediate IGF-I-induced cell cycle progression and can bind to a variety of translation initiation factors, thus controlling mitotic translation. In response to tumor growth, 14-3-3 s positively regulates the tumor suppressor p53 and increases the rate of p53-regulated inhibition of G2/M cell cycle progression. Multiple isoforms of 14-3-3 s exist due to alternative splicing events.
  • Concentration
    1ug per 1ul
  • Target Antigen
    14-3-3 sigma
  • Storage conditions
    Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
  • Cross-reactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Gene target
  • Short name
    14-3-3 sigma Antibody,
  • Technique
    Antibody
  • Alternative technique
    antibodies
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14 3 3 sigma Antibody ALEXA FLUOR - Gentaur.com
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