10-Hydroxycamptothecin

• Catalog number
  B1995-100
• Price
  Please ask
• Size
  100 mg

• Alternative_name
  (S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; NSC107124
• Description
  10-Hydroxycamptothecin is a potent topoisomerase I inhibitor. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound (Cat. No. 1039). 10-Hydroxycamptothecin displays strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC₅₀ = 1.15 μM).
• CAS Number
  19685-09-7 
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₀H₁₆N₂O₅
• Molecular Weight
  364.35
• Cell Permeable
  Yes
• Purity
  ≥95% by HPLC
• Solubilities
  DMSO (~3 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent topoisomerase I inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD00189425
• PubChem CID
  97226
• PubChem CID Link
• SMILES
  CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O
• InChi
  InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1
• InChi Key
  HAWSQZCWOQZXHI-FQEVSTJZSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  10-Hydroxycamptothecin  
• Gene symbol
  PIRC49, SNORD115-10, SNORD116-10, IGHV3OR16-10, IGKV2OR2-10, ERVK-10
• Short name
  10-Hydroxycamptothecin
• Alternative name
  10-Hydroxycamptothecin

Gene info

• Identity
  HGNC:37553
• Gene
  PIRC49
• Long gene name
  piwi-interacting RNA cluster 49
• Locus
  10
• Discovery year
  2009-11-05
• Entrez gene record
  100313929
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:33029
• Gene
  SNORD115-10
• Long gene name
  small nucleolar RNA, C/D box 115-10
• Synonyms
  • HBII-52-10
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033447
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003302.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:33076
• Gene
  SNORD116-10
• Long gene name
  small nucleolar RNA, C/D box 116-10
• Synonyms
  • HBII-85-10
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033422
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003325
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:5634
• Gene
  IGHV3OR16-10
• Long gene name
  immunoglobulin heavy variable 3/OR16-10 (non-functional)
• Synonyms gene name
  • immunoglobulin heavy variable 3/OR16-10
• Synonyms
  • IGHV3/OR16-10
• GenBank acession
  • Z29607
• Locus
  16p11.2
• Discovery year
  2000-04-17
• Entrez gene record
  28306
• Classification
  • Immunoglobulin heavy (IGH) orphons
• VEGA ID
  OTTHUMG00000176446

Gene info

• Identity
  HGNC:5806
• Gene
  IGKV2OR2-10
• Long gene name
  immunoglobulin kappa variable 2/OR2-10 (pseudogene)
• Synonyms gene name
  • immunoglobulin kappa variable 2/OR2-10
  • immunoglobulin kappa variable 2/OR2-10 pseudogene
• Synonyms
  • IGKV2/OR2-10
• GenBank acession
  • X51886
• Locus
  2q11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28855
• RefSeq identity
  • NG_011661
• Classification
  • Immunoglobulin kappa (IGK) orphons

Gene info

• Identity
  HGNC:39004
• Gene
  ERVK-10
• Long gene name
  endogenous retrovirus group K member 10
• Synonyms gene name
  • endogenous retrovirus group K, member 10
• Synonyms name
  • HERV-K_5q33.3 provirus ancestral Gag polyprotein
  • HERV-K_5q33.3 provirus Np9 protein
  • HERV-K_5q33.3 provirus ancestral Pol protein
  • HERV-K_5q33.3 provirus ancestral Pro protein
• GenBank acession
  • FN806835
  • CF227253
  • CN345079
  • AF164613
• Locus
  5q33.3
• Discovery year
  2011-05-05
• Entrez gene record
  100616101
• Pubmed identfication
  • 18664271
  • 15476554
  • 21542922

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