-
Category
Primary Antibodies
-
Long description
c-Myc participates in the regulation of gene transcription. It binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. It seems to activate the transcription of growth-related genes._x000B__x000B_Efficient DNA binding requires dimerization with another bHLH protein. Myc binds DNA as a heterodimer with MAX. It interacts with the follwing: TAF1C and SPAG9; PARP10; KDM5A and KDM5B; FBXW7 (when phosphorylated at Thr-58 and Ser-62); PIM2._x000B__x000B_POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differenciated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.
-
Antibody come from
Synthetic peptide derived from the human RRM1 protein
-
Other description
Provided as solution in phosphate buffered saline with 0.08% sodium azide. Protein A/G Chromatography
-
Clone
Myc A7
-
Antigen antibody binding interaction
Mouse anti Myc Tag Antibody
-
Antibody is raised in
Mouse
-
Antibody s reacts with
N terminus or C terminus of Myc tagged fusion proteins
-
Antibody s reacts with these species
This antibody doesn't cross react with other species
-
Antibody s specificity
No Data Available
-
Application
WB, Dt Blot, ELISA, IP, IS
-
Antibody s suited for
This antibody can be used for immunohistochemistry on formalin/paraffin sections (10-15 µg/ml). Optimal concentration should be evaluated by serial dilutions.
-
Storage
-20ºC
-
Relevant references
no information yet
-
Protein number
see ncbi
-
Warnings
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
-
-
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
-
Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
-
Latin name
Mus musculus
