Mouse anti Cytochrome P450 2A6
-
Catalog numberX2045M
-
PricePlease ask
-
Size200 μg
-
-
CategoryPrimary Antibodies
-
Long descriptionThe cytochrome P450 proteins (CYPs) are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP2A6 is a liver enzyme that metabolizes a number of drugs and a variety of procarcinogens, though it is primarily responsible for the metabolism of nicotine, the major addictive agent in tobacco. CYP2A6 inactivates nicotine to cotinine, and then cotinine to 3-hydroxycotinine. Differences in CYP2A6 genotypes are related to nicotine dependence, and may influence smoking habits and withdrawal symptoms in individuals that are quitting smoking. This suggests that an individualized smoking cessation program may be designed based on CYP2A6 genotypes._x000B__x000B_
-
Antibody come fromHybridoma produced by the fusion of splenocytes from BALB/c mice immunized with a synthetic peptide derived from the human TIMP-2 protein and mouse myeloma Ag8563 cells. Sequence common in mouse, rabbit, chicken, zebrafish and pig.
-
Other descriptionProvided as solution in phosphate buffered saline with 0.08% sodium azide. Protein A/G Chromatography
-
CloneF16 P2 D8
-
Antigen antibody binding interactionMouse anti Cytochrome P450 2A6 Antibody
-
Antibody is raised inMouse
-
Antibody s reacts withHuman
-
Antibody s reacts with these speciesThis antibody doesn't cross react with other species
-
Antibody s specificityNo Data Available
-
ApplicationELISA, Immunohistochemistry, Western Blot
-
Antibody s suited forAntibody can be used for ELISA, Western blotting (1-2 µg/ml) and immunohistochemistry on formalin-fixed, paraffin-embedded tissues (1-5 µg/ml). Optimal concentration should be evaluated by serial dilutions.
-
Storage-20ºC
-
Relevant references1. Hoikkala, S., et al. (2006). Tissue MMP-2 and MMP-9 [corrected] are better prognostic factors than serum MMP-2/TIMP-2--complex or TIMP-1 [corrected] in stage [corrected] I-III lung carcinoma. Cancer Lett. 236(1):125-132_x000B__x000B_2. Ring, P., et al. (1997). Expression of tissue inhibitor of metalloproteinases TIMP-2 in human colorectal cancer--a predictor of tumour stage. Br. J. Cancer. 76(6):805-811.
-
Protein numbersee ncbi
-
WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
-
DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
-
TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
-
Latin nameMus musculus
-
Gene target
-
Gene symbolCYP3A7, CYP24A1, CYP1A1, CYP51A1, CYP2D6
-
Short nameMouse anti Cytochrome P450 2A6
-
TechniqueMouse, anti, antibody to, mouses
-
Hostmouse
-
IsotypeIgG1
-
Labelunlabeled
-
SpeciesMouse, Mouses
-
Alternative nameMouse antibody to Cytochrome P450 2A6
-
Alternative techniquemurine, antibodies
-
Gene info
-
Identity
-
Gene
-
Long gene namecytochrome P450 family 3 subfamily A member 7
-
Synonyms gene name
- cytochrome P450, subfamily IIIA, polypeptide 7
- cytochrome P450, family 3, subfamily A, polypeptide 7
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1992-09-14
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Cytochrome P450 family 3
-
VEGA ID
-
Locus Specific Databases
Gene info
-
Identity
-
Gene
-
Long gene namecytochrome P450 family 24 subfamily A member 1
-
Synonyms gene
-
Synonyms gene name
- cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase)
- cytochrome P450, family 24, subfamily A, polypeptide 1
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1992-09-09
-
Entrez gene record
-
Classification
- Cytochrome P450 family 24
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namecytochrome P450 family 1 subfamily A member 1
-
Synonyms gene
-
Synonyms gene name
- cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1
- cytochrome P450, family 1, subfamily A, polypeptide 1
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1986-01-01
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Cytochrome P450 family 1
-
VEGA ID
-
Locus Specific Databases
Gene info
-
Identity
-
Gene
-
Long gene namecytochrome P450 family 51 subfamily A member 1
-
Synonyms gene
-
Synonyms gene name
- cytochrome P450, 51 (lanosterol 14-alpha-demethylase)
- cytochrome P450, family 51, subfamily A, polypeptide 1
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1996-10-26
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Cytochrome P450 family 51
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namecytochrome P450 family 2 subfamily D member 6
-
Synonyms gene
-
Synonyms gene name
- cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6
- cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2
- cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2
- cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2
- cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2
- cytochrome P450, family 2, subfamily D, polypeptide 6
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1992-04-07
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Cytochrome P450 family 2
-
VEGA ID
-
Locus Specific Databases
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data