ACE Antibody

• Catalog number
  R31546
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  ACE
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P, IHC-F
• Recommended dilutions
  Western blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml,IHC (Frozen): 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the ACE antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This ACE antibodyis to be used only for research purposes and not for diagnostics..
• Gene ID
  1636
• Purity
  Antigen affinity
• Description
  Angiotensin-converting enzyme, an exopeptidase, is a circulating enzyme that participates in the body's renin-angiotensin system(RAS), which mediates extracellular volume (i.e. that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. It is secreted by pulmonary and renal endothelial cells and catalyzes the conversion of decapeptide angiotensin I to octapeptide angiotensin II. Using a DNA marker at the growth hormone gene locus, which they characterized as 'extremely polymorphic' and which showed no recombination with ACE, the gene was mapped to 17q22-q24, consistent with the in situ hybridization mapping to 17q23. ACE, or kininase II, is a dipeptidyl carboxypeptidase that plays an important role in blood pressure regulation and electrolyte balance by hydrolyzing angiotensin I into angiotensin II, a potent vasopressor, and aldosterone-stimulating peptide. The enzyme is also able to inactivate bradykinin, a potent vasodilator.
• Immunogen
  Human partial recombinant protein (AA 651-864) was used as the immunogen for this ACE antibody.
• Storage
  After reconstitution, the ACE antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ACE  
• Gene symbol
  ACE
• Short name
  Anti-ACE
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to ACE
• Alternative technique
  antibodies
• Alternative to gene target
  Angiotensin-converting enzyme; Uncharacterized protein, ACE and IDBG-728302 and ENSG00000264813 and, peptidyl-dipeptidase activity, Plasma membranes

Gene info

• Identity
  HGNC:2707
• Gene
  ACE
• Long gene name
  angiotensin I converting enzyme
• Synonyms gene
  • DCP1
• Synonyms gene name
  • angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
• Synonyms
  • ACE1
  • CD143
• Synonyms name
  • peptidyl-dipeptidase A
• GenBank acession
  • J04144
• Locus
  17q23.3
• Discovery year
  1989-06-06
• Entrez gene record
  1636
• Pubmed identfication
  • 2554286
  • 10319862
• RefSeq identity
  • NM_000789
• Classification
  • CD molecules
• VEGA ID
  OTTHUMG00000154927

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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