ABCC4 Antibody

• Catalog number
  R30966
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  ABCC4
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the ABCC4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This ABCC4 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  O15439
• Purity
  Antigen affinity
• Description
  ATP-binding cassette, subfamily c, member 4, also known as MRP4 or MOATB, is a protein that in humans is encoded by the ABCC4 gene. The protein belongs to a large family of transmembrane proteins involved in active transport of substrates out of cells. By radiation hybrid analysis, Kool et al.(1997) mapped the gene to chromosome 13. Using FISH, Lee et al.(1998) refined the localization to chromosome 13q32. ABCC4 acts as an independent regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus. The antiproliferative effect of ABCC4 inhibition was related to cAMP-dependent PKA activation and CREB phosphorylation. Pharmacologic inhibition of protein activity or knockdown via RNA interference resulted in reduced migration of DCs from human skin explants and of in vitro-generated Langerhans cells. Van de Ven et al.(2008) concluded that the protein contributes to migration of DCs toward draining lymph nodes and therefore has a role in the initiation of an immune response.
• Immunogen
  An amino acid sequence from the N-terminus of human ABCC4/MRP4 (WLNPLFKIGHKRRLEEDD) was used as the immunogen for this ABCC4 antibody.
• Storage
  After reconstitution, the ABCC4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ABCC4  
• Gene symbol
  ABCC4
• Short name
  Anti-ABCC4
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to ABCC4
• Alternative technique
  antibodies
• Alternative to gene target
  ATP-binding cassette, sub-family C (CFTR/MRP), member 4, MOAT-B and MOATB and MRP4, ABCC4 and IDBG-42534 and ENSG00000125257 and 10257, ATPase activity, Plasma membranes, Abcc4 and IDBG-186342 and ENSMUSG00000032849 and 239273, BT.93156 and IDBG-632162 and ENSBTAG00000032603 and 515333

Gene info

• Identity
  HGNC:55
• Gene
  ABCC4
• Long gene name
  ATP binding cassette subfamily C member 4
• Synonyms gene name
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 4
• Synonyms
  • MRP4
  • EST170205
  • MOAT-B
  • MOATB
• Synonyms name
  • canalicular multispecific organic anion transporter (ABC superfamily)
  • bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4)
  • multidrug resistance-associated protein 4
  • multispecific organic anion transporter B
• GenBank acession
  • U66682
• Locus
  13q32.1
• Discovery year
  1999-10-26
• Entrez gene record
  10257
• Pubmed identfication
  • 8894702
  • 9661885
• RefSeq identity
  • NM_005845
• Classification
  • ATP binding cassette subfamily C
• VEGA ID
  OTTHUMG00000017216
• Locus Specific Databases
  • LRG_1183

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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