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Products_type
Antibody
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Products_short_name
[CD8 ALPHA]
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Products_name_syn
[CD8 Alpha; LY-2; Lyt2; Lyt-2]
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Other_names
[T-cell surface glycoprotein CD8 alpha chain isoform 1; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 alpha chain; Lyt-2.1 lymphocyte differentiation antigen (AA at 100); T-cell surface glycoprotein Lyt-2; CD8 antigen, alpha chain; T-cell surface glycoprotein Lyt-2; CD_antigen: CD8a]
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Products_gene_name
[CD8]
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Other_gene_names
[Cd8a; Cd8a; Ly-2; Ly-B; Ly-35; Lyt-2; BB154331; Lyt-2; Lyt2]
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Clonality
Monoclonal
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Clone
[YTS105.18]
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Reactivity
Mouse
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Specificity
Rat anti Mouse CD8, clone YTS105.18 recognizes a non polymorphic epitope on the mouse CD8 alpha chain. This antibody has been reported to block MHC I dependent T cell responses in vitro and in vivo and induces transplantation tolerance in combination with CD4 antibodies.
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Form
Purified IgG - liquid; Phosphate buffered saline
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Concentration
IgG concentration 1 mg/ml
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Storage_stability
Store at 4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
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Tested_application
Immunohistology-Frozen, Flow cytometry (FC/FACS), Immunofluorescence (IF)
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. This is against a protein of mus musculus directed antibody. Cytotoxic T cells cluster differentiators for flow cytometry. This transmembrane glycoprotein is detected by monoclonals and has a lot of clones available with different affinity.
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Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus, Rattus norvegicus
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About
Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
