RABBIT ANTI MOUSE MDM2
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Catalog numberMBS222809
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PricePlease ask
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Size5x0.05 mg
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Products_typeAntibody
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Products_short_name[MDM2]
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Other_names[E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase Mdm2; double minute 2 protein; oncoprotein Mdm2; p53-binding protein Mdm2; transformed mouse 3T3 cell double minute 2; Double minute 2 protein; Oncoprotein Mdm2; p53-binding protein Mdm2]
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Products_gene_name[MDM2]
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Other_gene_names[Mdm2; Mdm2; Mdm-2; AA415488; 1700007J15Rik]
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ClonalityPolyclonal
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SpecificityThis item detects murine Mdm2, a nuclear phosphoprotein that controls intracellular levels of the tumour suppressor protein p53 by ubiquitination and subsequent proteasomal degradation. Mdm2 also interacts with the retinoblastoma (RB) protein and E2F-1, to promote G1-S phase transition in the cell cycle. Mdm2 activity is controlled by self-ubiquitination; however activation of the PI3K/PKB pathway leads to phosphorylation of Mdm2 at Ser185, which stabilises the protein.
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FormPurified Purified IgG - liquid
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ConcentrationIgG concentration 0.5mg/ml
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Storage_stabilityStore at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
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Tested_applicationELISA (EIA), Western Blot (WB)
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. This is against a protein of mus musculus directed antibody.
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TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin nameMus musculus, Oryctolagus cuniculus
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AboutRabbits are used for polyclonal antibody production by MyBioSource. Rabbit antibodies are very stable and can be stored for several days at room temperature. MyBioSource adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Gene target
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Gene symbolMDM2
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Short nameRABBIT ANTI MOUSE MDM2
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Techniqueanti mouse, Rabbit, Mouse, anti, antibody to, anti mouse antibodies, mouses
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HostRabbit, Rabbits
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IsotypeIgG
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SpeciesMouse, Mouses
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Alternative nameproduction species: rabbit antibody to MOUSE MDM2
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Alternative techniquerabbit-anti, murine, antibodies
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Gene info
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Identity
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Gene
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Long gene nameMDM2 proto-oncogene
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Synonyms gene name
- mouse double minute 2, human homolog of; p53-binding protein
- Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse)
- Mdm2 p53 binding protein homolog (mouse)
- MDM2 proto-oncogene, E3 ubiquitin protein ligase
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Synonyms
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Locus
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Discovery year1993-12-10
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Zinc fingers RANBP2-type
- Ring finger proteins
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
