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Products_type
Antibody
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Products_short_name
[NFkB p52]
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Products_name_syn
[Anti -NFkB p52 (NF Kappa B, Nuclear Factor kappa B)]
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Other_names
[nuclear factor NF-kappa-B p100 subunit isoform b; Nuclear factor NF-kappa-B p100 subunit; nuclear factor NF-kappa-B p100 subunit; oncogene Lyt-10; DNA-binding factor KBF2; lymphocyte translocation chromosome 10 protein; nuclear factor of kappa light chain gene enhancer in B-cells 2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100); DNA-binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10 protein; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; Oncogene Lyt-10]
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Other_gene_names
[NFKB2; NFKB2; p52; p105; H2TF1; LYT10; LYT-10; NF-kB2; LYT10; Lyt10]
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Clonality
Polyclonal
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Reactivity
Human
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Specificity
Recognizes human NF KB, p52, (52kD) and its 110kD precursor.
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Purity
Affinity Purified Purified by Protein A affinity chromatography.
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Form
Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 150 mM NaCl, with 0.05% sodium azide.
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Storage_stability
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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Tested_application
Western Blot (WB), Immunoprecipitation (IP)
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Description
Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.
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Gene
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (κ light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory
